12 August 2008
Vol 1, Issue 32
  • Contents

    • Perspective

    • Editors' Choice

      • The Benefits of Exercise Without the Sweat

        Mice given a drug that activates AMPK exhibit increased endurance and alterations in skeletal muscle that are similar to those achieved by exercise.

      • Fleeing Overexposure

        C. elegans exhibits a locomotive response to ultraviolet light mediated through a protein unrelated to known photoreceptors.

      • T Cells Set Bone Response

        T cells use CD40L (a ligand) to instruct bone marrow stromal cells to respond to parathyroid hormone.

      • Back from the Dead

        Microinjection of receptor mRNAs and membrane preparations from postmortem normal and diseased brains into Xenopus oocytes enables comparative analysis of receptor function.

      • Coupling Secretion with Transcription

        Secretion of a transcription factor regulates production of the Mycobacterium tuberculosis secretion system.

      • Fatty Acid-Regulated Diapause

        In nematodes, developmental arrest induced by a fatty acid deficiency is insulin-independent.

      • Avoiding a Traffic Jam

        Arrival of cargo stimulates Golgi trafficking by means of the KDEL receptor and Src family tyrosine kinases.

      • Axonal Pathfinding in Sight

        A signaling protein that helps nerve fibers find their correct target muscles is required for innervation of the eye muscles and, if defective, causes an eye movement disorder.

      • Modulating Striatal Synapses

        Contrary to previous assumptions, dopamine helps both strengthen and weaken synapses made by cortical cells onto cells of the subcortical striatum.

About The Cover

Cover image expansion

COVER This week's issue features a Perspective that discusses the dynamic nature of proteins associated with the sarcomeres of skeletal and cardiac muscle. The central portion of the image depicts a sarcomere, the contractile unit of a myofibril. [Image: Chris Bickel, AAAS]