Contents
Vol 1, Issue 33
Contents
Perspectives
- Dinucleotide-Sensing Proteins: Linking Signaling Networks and Regulating Transcription
Proteins that bind NAD(H) or NADP(H) may couple cellular redox state to transcription or other signaling pathways.
- Great Times for Small Molecules: c-di-AMP, a Second Messenger Candidate in Bacteria and Archaea
The bacterial checkpoint protein DisA has diadenylate cyclase activity, suggesting that c-di-AMP acts as a second messenger.
Editors' Choice
- Food for Thought
A hormone’s effect on feeding behavior is mediated by effects on mitochondrial metabolism in hippocampal neurons.
- Reconsidering Redundancy
Two closely related phosphatase regulatory subunits have opposing effects on TGF-β signaling.
- A Life or Death Decision
MALT1 activation of caspase-8 leads to altered substrate specificity and proliferative signaling.
- Capable Caspase
Caspase-3 cleaves signaling proteins in nonapoptotic, anergic T cells to inhibit T cell receptor signaling and maintain hyporesponsiveness.
- RNA Interference and Plant Defenses
Upon bacterial infection, Arabidopsis mounts a microRNA-mediated innate immune defense, which is inhibited by proteins of the bacteria, allowing other infections.
- Nuts and Bolts of Plant Pathogen Response
After a pathogen invades a plant, a protein, usually kept in a multimeric state by S-nitrosylation, is dissociated by thioredoxin, freeing the monomers for defense responses.
