19 August 2008
Vol 1, Issue 33
  • Contents

    • Perspectives

    • Editors' Choice

      • Food for Thought

        A hormone’s effect on feeding behavior is mediated by effects on mitochondrial metabolism in hippocampal neurons.

      • Reconsidering Redundancy

        Two closely related phosphatase regulatory subunits have opposing effects on TGF-β signaling.

      • A Life or Death Decision

        MALT1 activation of caspase-8 leads to altered substrate specificity and proliferative signaling.

      • Capable Caspase

        Caspase-3 cleaves signaling proteins in nonapoptotic, anergic T cells to inhibit T cell receptor signaling and maintain hyporesponsiveness.

      • RNA Interference and Plant Defenses

        Upon bacterial infection, Arabidopsis mounts a microRNA-mediated innate immune defense, which is inhibited by proteins of the bacteria, allowing other infections.

      • Nuts and Bolts of Plant Pathogen Response

        After a pathogen invades a plant, a protein, usually kept in a multimeric state by S-nitrosylation, is dissociated by thioredoxin, freeing the monomers for defense responses.

About The Cover

Cover image expansion

COVER This week's issue features a Perspective that discusses how the binding of dinucleotides such as NAD(H) or NADP(H) to certain regulatory proteins modulates changes in gene transcription and physiological state. The image shows an asymmetric dimer of the NADP-binding protein HSCARG. [Image: Chris Bickel, AAAS]