26 August 2008
Vol 1, Issue 34
  • Contents

    • Protocol

    • Presentation

    • Editors' Choice

      • A Cryptic Response?

        Cryptochrome appears to play a critical role in fruit fly magnetoreception.

      • Telling Polys Apart

        Antibodies have been developed that differentiate between polyubiquitin chains that target proteins for degradation and those that enhance protein function.

      • Becoming Brown Fat

        Insights into the differentiation of brown adipocytes may lead to unexplored approaches to treating obesity.

      • Sensing Alarm

        A mysterious ganglion at the tip of the nose is an olfactory subsystem that senses alarm pheromones in mice.

      • Jam the Signal

        A small, nontoxic antibiotic candidate interferes with bacterial detection of the host and inhibits infection, in a therapeutic approach that may avoid development of resistance.

      • Fixed But Flexible

        Variations in component levels of the antigen-induced signaling pathway affect the final response of activated immune cells, conferring flexibility on the system.

      • To Divide or Not to Divide

        For quiescent cells to periodically divide and then rest, a member of the Notch signaling pathway HES1 must be present; this protein is also activated in some tumors.

About The Cover

Cover image expansion

COVER This week's issue features a Protocol that describes how to apply mechanical stress to a cell and measure its effects on intracellular signaling pathways. The image shows a cell with an attached ferromagnetic bead mounted above an inverted microscope. [Image: Preston Huey, AAAS]