02 September 2008
Vol 1, Issue 35
  • Contents

    • Editorial Guide

    • Research Articles

    • Perspective

    • Review

    • Editors' Choice

      • GRK Versus HDAC

        G protein-coupled receptor kinase 5 (GRK5) phosphorylates HDAC5, thus allowing the transcription of genes involved in cardiac hypertrophy.

      • Microglial Messages Modulate Neurogenesis

        Microglial signaling factors are critical to inhibition of adult hippocampal neurogenesis by presenilin 1 variants associated with familial Alzheimer's disease.

      • Dynein Light Chain Connecting ROS to NF-κB

        Reversible oxidation of dynein light chain contributes to activation of NF-κB by stimuli that produce reactive oxygen species.

      • Maintaining Organ Integrity

        FGF signaling directs both homeostatic and facultative regeneration in zebrafish fins.

      • Channel Opening

        Circularly arrayed transmembrane helices tilt to facilitate the opening of a bacterial mechanosensitive channel.

      • Rainbow Signals

        In addition to an antiseptic function, phenazines—pigmented antibiotics made by bacteria—organize colony structure by activating a superoxidative stress regulator.

      • VDAC-1 Structure in Solution

        A channel that allows diffusion of metabolites across the mitochondrial outer membrane forms an unusual 19-stranded β barrel with a pore size of about 25 angstroms.

About The Cover

Cover image expansion

COVER In this week's issue, Science Signaling launches the publication of primary research articles. The first Research Article describes the importance of the extracellular calcium-sensing receptor (CaSR) to embryonic and postnatal skeletal development. The image shows the skeletons of control, heterozygous, and homozygous knockout mice for Casr in parathyroid cells. [Image: Wenhan Chang, UCSF]