Contents
Vol 1, Issue 35
Contents
Editorial Guide
- Seeing the Signaling Forest and the Trees
Science Signaling launches primary research to meet the needs of the signal transduction community.
Research Articles
- The Extracellular Calcium-Sensing Receptor (CaSR) Is a Critical Modulator of Skeletal Development
The extracellular calcium-sensing receptor (CaSR) is essential for embryonic and postnatal skeletal development.
- Linear Motif Atlas for Phosphorylation-Dependent Signaling
Created with both in vitro and in vivo data, NetPhorest is an atlas of consensus sequence motifs for 179 kinases and 104 phosphorylation-dependent binding domains and reveals new insight into phosphorylation-dependent signaling.
Perspective
- New Insights in Bone Biology: Unmasking Skeletal Effects of the Extracellular Calcium–Sensing Receptor
Embryonic and postnatal development of the skeleton requires the functions of the extracellular calcium-sensing receptor (CaSR).
Review
- Alternative Wnt Signaling Is Initiated by Distinct Receptors
The traditional classification of Wnts into canonical or noncanonical proteins may be misleading.
Editors' Choice
- GRK Versus HDAC
G protein-coupled receptor kinase 5 (GRK5) phosphorylates HDAC5, thus allowing the transcription of genes involved in cardiac hypertrophy.
- Microglial Messages Modulate Neurogenesis
Microglial signaling factors are critical to inhibition of adult hippocampal neurogenesis by presenilin 1 variants associated with familial Alzheimer's disease.
- Memory Formation Enhanced by Circadian Signaling
Memory is improved in mice that learn during the circadian peak of ERK and cAMP signaling.
- Dynein Light Chain Connecting ROS to NF-κB
Reversible oxidation of dynein light chain contributes to activation of NF-κB by stimuli that produce reactive oxygen species.
- Maintaining Organ Integrity
FGF signaling directs both homeostatic and facultative regeneration in zebrafish fins.
- Channel Opening
Circularly arrayed transmembrane helices tilt to facilitate the opening of a bacterial mechanosensitive channel.
- Rainbow Signals
In addition to an antiseptic function, phenazines—pigmented antibiotics made by bacteria—organize colony structure by activating a superoxidative stress regulator.
- VDAC-1 Structure in Solution
A channel that allows diffusion of metabolites across the mitochondrial outer membrane forms an unusual 19-stranded β barrel with a pore size of about 25 angstroms.
