Research ArticleDevelopment

The Extracellular Calcium-Sensing Receptor (CaSR) Is a Critical Modulator of Skeletal Development

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Science Signaling  02 Sep 2008:
Vol. 1, Issue 35, pp. ra1
DOI: 10.1126/scisignal.1159945

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  • Response to Quarles and Pi

    In attempting to reconcile their observations on the lack of bone defects in generalized extracellular calcium-sensing receptor (CaSR) knockout (KO) mice rescued from severe hyperparathyroidism (HPT) with our findings of profound skeletal phenotypes in the osteoblast- and chondrocyte-specific CaSR knockout mice (1), Drs. Quarles and Pi propose that the extracellular domain of the CaSR (∆Exon7-CaSR), encoded by exons 2 to 6 of...

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    Competing Interests: None declared.
  • Calcium-Sensing Receptor Function in the Skeleton: Alternative Interpretations

    The current Research Article by Chang et al. (1) addresses a long-standing question regarding the function of the extracellular calcium-sensing receptor (CaSR) in the skeleton. It is well known that the major physiologic function of the CaSR is to regulate systemic calcium homeostasis, through its actions in the parathyroid gland to regulate parathyroid hormone (PTH) secretion and in the kidney to regulate renal calciu...

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    Competing Interests: None declared.

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