Linear Motif Atlas for Phosphorylation-Dependent Signaling

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Sci. Signal.  02 Sep 2008:
Vol. 1, Issue 35, pp. ra2
DOI: 10.1126/scisignal.1159433

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An Atlas of Phosphorylation

NetPhorest is a community resource that uses phylogenetic trees to organize data from both in vivo and in vitro experiments to derive sequence specificities for 179 kinases and 104 domains (SH2, PTB, BRCT, WW, and 14–3–3) that bind to phosphorylated sites. The resulting atlas of linear motifs revealed that oncogenic kinases tend to be less specific in the target sequences they phosphorylate than their non-oncogenic counterparts, that autophosphorylation sites tend to be more variable than other substrates of a given kinase, and that coupling interaction domains with kinase domains may allow phosphorylation site specificity to be low while still maintaining substrate specificity.