Contents
Vol 1, Issue 36
Contents
Research Article
- Phosphoinositide 3-Kinase p110β Activity: Key Role in Metabolism and Mammary Gland Cancer but Not Development
The phosphoinositide 3-kinase p110β subunit has noncatalytic functions; its catalytic activity is pertinent to both diabetes and cancer.
Perspective
- Smad Signaling Dynamics: Insights from a Parsimonious Model
Computational modeling of protein localization dynamics yields new information about Smad signaling.
Editors' Choice
- Big Brother's a Bully
In Caenorhabditis elegans, a large noncoding RNA inhibits the complex that produces small RNAs.
- What Are Dimers Good For?
The assembly of scaffold proteins and ERK dimers is required for the activation of cytoplasmic, but not nuclear, substrates.
- Ligand Not Required?
A ligand may not be necessary for the nuclear receptor PPARγ to promote adipogenesis.
- Getting to the Right Place
Neurogenin 2 transcriptionally activates the small GTP-binding protein Rnd2 to regulate migration of cortical neurons.
- Signaling from the Right Place
Type IV collagens influence localization of the morphogen Dpp in Drosophila embryos and ovaries.
- Wnt Receptor Signaling
The interaction of the signaling molecule Wnt with its receptor triggers accumulation of a lipid regulator, which stimulates phosphorylation of the receptor and cellular responses.
- Quantity, Not Just Quality, Matters
In patients with colorectal cancer, one allele of the transforming growth factor–β gene produces less mRNA and thus less protein, a likely contributor to disease risk.
- Multifunctional SH2 Domains
Crystal structures reveal how SH2 protein interaction domains can both enhance and inhibit activity of cytoplasmic tyrosine kinases.
