30 September 2008
Vol 1, Issue 39
  • Contents

    • Research Articles

    • Perspective

      • A Wnt-fall for Gene Regulation: Repression

        Recognition of a nonclassical Wnt-response element by the transcription factor TCF results in β-catenin acting as a transcriptional repressor of certain Wnt target genes.

    • Presentation

    • Editors' Choice

      • β-Blockers: Both Antagonist and Agonist

        Select drugs that inhibit β-adrenergic receptor-mediated activation of G proteins stimulate signaling through β-arrestin.

      • Social Signaling

        Pheromone signaling depends on social context.

      • Entry Code

        Phosphorylation of serine residues within a short motif triggers the nuclear translocation of various signaling proteins in a nuclear localization signal–independent manner.

      • Converging on β-Catenin

        Studies by two groups converge to implicate the cyclin-dependent kinase CDK8 in the pathogenesis of colorectal cancer.

      • Rethinking Cancer Metastasis

        In mice, normal mammary cells can colonize the lung, suggesting that metastases might arise from displaced normal cells acquiring genetic changes that confer malignancy.

      • Cystic Fibrosis Remodeled

        Newborn pigs carrying a mutated copy of the gene defective in cystic fibrosis exhibit many features of the human disease and may provide fresh insights for therapy.

      • Recognition Receptor Revealed

        The receptor that binds antigens in jawless vertebrates differs from the immunoglobulins of jawed vertebrates and uses a variable concave surface and carboxyl terminal for recognition.

About The Cover

Cover image expansion

COVER This week's issue features a Research Article that demonstrates how ATP, released through pannexin hemichannels, signals in an autocrine fashion through purinergic receptors on activated T cells to provide a costimulatory signal. The authors showed that inhibition of ATP signaling reduced inflammation in mouse models of diabetes and inflammatory bowel disease. The image shows a stained section of colon from a healthy mouse, with goblet cells (pink droplets) lining colonic crypts. [Image: Enrico Radaelli, University of Milan, Italy]