Contents
Vol 1, Issue 39
Contents
Research Articles
- Purinergic Control of T Cell Activation by ATP Released Through Pannexin-1 Hemichannels
Pannexin hemichannel–mediated release of ATP provides an autocrine, costimulatory signal for T cell activation.
- Kinome siRNA Screen Identifies Regulators of Ciliogenesis and Hedgehog Signal Transduction
Cdc2l1is a component of the Hh signaling pathway and opposes the activity of the negative regulator Sufu.
Perspective
- A Wnt-fall for Gene Regulation: Repression
Recognition of a nonclassical Wnt-response element by the transcription factor TCF results in β-catenin acting as a transcriptional repressor of certain Wnt target genes.
Presentation
- Somatic Cell Genetics for the Study of NF-κB Signaling in Innate Immunity
A forward genetic screen in immortalized cells identifies NF-κB signaling components required to transduce signals from Toll-like receptors.
Editors' Choice
- β-Blockers: Both Antagonist and Agonist
Select drugs that inhibit β-adrenergic receptor-mediated activation of G proteins stimulate signaling through β-arrestin.
- Entry Code
Phosphorylation of serine residues within a short motif triggers the nuclear translocation of various signaling proteins in a nuclear localization signal–independent manner.
- Converging on β-Catenin
Studies by two groups converge to implicate the cyclin-dependent kinase CDK8 in the pathogenesis of colorectal cancer.
- Cancer Genomes: From Chaos Comes Order?
Genomic analyses identify genes disrupted in pancreatic tumors and glioblastoma multiforme.
- Rethinking Cancer Metastasis
In mice, normal mammary cells can colonize the lung, suggesting that metastases might arise from displaced normal cells acquiring genetic changes that confer malignancy.
- Cystic Fibrosis Remodeled
Newborn pigs carrying a mutated copy of the gene defective in cystic fibrosis exhibit many features of the human disease and may provide fresh insights for therapy.
- Recognition Receptor Revealed
The receptor that binds antigens in jawless vertebrates differs from the immunoglobulins of jawed vertebrates and uses a variable concave surface and carboxyl terminal for recognition.
