Contents
Vol 1, Issue 4
Contents
Perspective
- Human ITPK1: A Reversible Inositol Phosphate Kinase/Phosphatase That Links Receptor-Dependent Phospholipase C to Ca2+-Activated Chloride Channels
Studies of ITPK1 reveal subtle interconnections between simple metabolism and regulation of a signaling event.
Editors' Choice
- GABA Stems Proliferation
GABA regulates stem cell proliferation through a pathway that uses components of the DNA damage checkpoint response.
- Activating Aurora
A kinase that regulates chromosome segregation to daughter cells during metaphase is confined to the inner centromere through its interactions with other centromeric proteins.
- FAK Goes Nuclear
Focal adhesion kinase acts as a scaffold protein in the nucleus to target p53 for degradation and promote cell proliferation.
- Homering In on T Cell Activation
Signals coming into the T cell are coordinated by two scaffolding proteins, which determine whether the cell will be activated or permanently shut down.
- Stop and Go Signals
JNK regulates the phosphorylation status and trafficking of AMPA-type glutamate receptors in response to neuronal activity.
- Calcium Signals Prime Macrophages
Crosstalk between DAP12-coupled receptors and the IFN-α receptor enhance activation of STAT1 by IFN-α.
- It’s the Kinase, Stupid!
Opposite effects of the same receptor on cell migration are explained by coupling to either of two distinct tyrosine kinases.
- Hearing About Glutamate Transporters
VGLUT3 is critical to hearing and involved in regulation of cortical excitability.
- How Yeast Responds to Change
Modeling the dynamics of the osmotic stress response in yeast reveals an unexpected, rapid nontranscriptional mechanism that may involve glycerol transport.
- Fast and Slow
A yeast transcription factor binds onto and off its promoter rapidly, controlling initiation, but also shows a 30-minute cycle as the number of accessible promoters varies.
