29 January 2008
Vol 1, Issue 4
  • Contents

    • Perspective

    • Editors' Choice

      • GABA Stems Proliferation

        GABA regulates stem cell proliferation through a pathway that uses components of the DNA damage checkpoint response.

      • Activating Aurora

        A kinase that regulates chromosome segregation to daughter cells during metaphase is confined to the inner centromere through its interactions with other centromeric proteins.

      • FAK Goes Nuclear

        Focal adhesion kinase acts as a scaffold protein in the nucleus to target p53 for degradation and promote cell proliferation.

      • Homering In on T Cell Activation

        Signals coming into the T cell are coordinated by two scaffolding proteins, which determine whether the cell will be activated or permanently shut down.

      • Stop and Go Signals

        JNK regulates the phosphorylation status and trafficking of AMPA-type glutamate receptors in response to neuronal activity.

      • Calcium Signals Prime Macrophages

        Crosstalk between DAP12-coupled receptors and the IFN-α receptor enhance activation of STAT1 by IFN-α.

      • It’s the Kinase, Stupid!

        Opposite effects of the same receptor on cell migration are explained by coupling to either of two distinct tyrosine kinases.

      • How Yeast Responds to Change

        Modeling the dynamics of the osmotic stress response in yeast reveals an unexpected, rapid nontranscriptional mechanism that may involve glycerol transport.

      • Fast and Slow

        A yeast transcription factor binds onto and off its promoter rapidly, controlling initiation, but also shows a 30-minute cycle as the number of accessible promoters varies.

About The Cover

Cover image expansion

COVER This week's issue features a Perspective on the inositol phosphatase and kinase ITPK1 (inositol 1,3,4-triphosphate 5/6 kinase). The image is human ITPK1 based on PDB 2odt. [Image: Christopher Bickel, AAAS]