07 October 2008
Vol 1, Issue 40
  • Contents

    • Presentation

    • Podcast

    • Editors' Choice

      • Why Albinism Impairs Eyesight

        L-DOPA, an intermediate in melanin synthesis, stimulates an orphan G protein-coupled receptor to trigger release of a trophic factor from the retinal pigmented epithelia.

      • Putting the STING in Innate Immunity

        A protein associated with protein transport machinery in the endoplasmic reticulum appears to function in signaling detection of viral infection.

      • Apoptosis by Another Route

        In worms, lipid signaling at the mitochondria is necessary for the germ-cell death that follows radiation damage but not for normal developmental cell death.

      • Homing In on the Hub

        The stressosome, a huge multiprotein complex, has a virus capsid–like core and variable extensions that detect and integrate signals to activate the stress response.

      • Sticking Together

        Chemokine signaling is required for migration of endoderm in the zebrafish embryo, not as a chemoattractant but as a regulator of cell adhesion.

About The Cover

Cover image expansion

COVER This week's issue features a Podcast in which Science Signaling editors discuss research about how the bacteria that cause periodontitis can evade the immune system. [Image: Jupiterimages]