Contents
Vol 1, Issue 40
Contents
Presentation
- The Endothelial Glycocalyx: A Mechano-Sensor and -Transducer
A complex extracellular network of proteoglycans communicates mechanical stress to endothelial cells.
Podcast
- Science Signaling Podcast: 07 October 2008
The bacteria that cause periodontitis evade destruction by promoting crosstalk between two receptors that regulate the immune response.
Editors' Choice
- Synaptic Signaling to a Separate Population?
Spontaneous and evoked glutamate release may activate different populations of NMDA receptors.
- Why Albinism Impairs Eyesight
L-DOPA, an intermediate in melanin synthesis, stimulates an orphan G protein-coupled receptor to trigger release of a trophic factor from the retinal pigmented epithelia.
- Putting the STING in Innate Immunity
A protein associated with protein transport machinery in the endoplasmic reticulum appears to function in signaling detection of viral infection.
- More Than Just Constitutively Active
EGFR and EGFRvIII activate target gene expression through distinct mechanisms.
- Kinase-Independent Signaling from TGF-β Receptors to TAK1
TGF-β signals through the type I receptor to trigger Lys63-linked ubiquitylation and activation of the kinase TAK1.
- Stressing the Response to an Inflamed Hypothalamus
Hypothalamic IKKβ-NF-κB signaling plays a critical role in the metabolic response to overnutrition.
- Apoptosis by Another Route
In worms, lipid signaling at the mitochondria is necessary for the germ-cell death that follows radiation damage but not for normal developmental cell death.
- Homing In on the Hub
The stressosome, a huge multiprotein complex, has a virus capsid–like core and variable extensions that detect and integrate signals to activate the stress response.
- Sticking Together
Chemokine signaling is required for migration of endoderm in the zebrafish embryo, not as a chemoattractant but as a regulator of cell adhesion.
