14 October 2008
Vol 1, Issue 41
  • Contents

    • Research Articles

    • Perspective

    • Editors' Choice

      • Sugar Sensor

        A receptor senses glucose and contributes to metabolic regulation in the fruit fly.

      • Seeing About Succinate

        Succinate signals through a G protein-coupled receptor to promote retinal angiogenesis.

      • More Light, Less Disease

        Excess light changes the redox status of the chloroplast plastoquinone pool, which triggers both responses involved in acclimation to the light and pathogen defense.

      • Taking It Slow

        By increasing the half-lives of peptide-MHC complexes on dendritic cells, TLR ligands lead to increased T cell receptor activation in CD8+ T cells.

      • Hindering Herpes

        Herpes virus in neurons can be kept in a latent state by T cells, which release granzyme B, an inhibitor of a protein necessary for viral gene expression.

      • T Regulation of Dendritic Cells

        A protein in T regulatory cells controls their ability to dampen activation of the immune system by antigen-presenting cells, preventing autoimmune disease.

      • Inhibiting ENaC Activation

        Proteolytic activation of epithelial sodium channels is inhibited by increased intracellular sodium.

About The Cover

Cover image expansion

COVER This week's issue features a Research Article that demonstrates how the calcium-sensitive protein VILIP1 binds to and modulates the mobility and activity of the purinergic receptor P2X2. The cover is based on an image that shows FRET interactions between P2X2-CFP and VILIP1-YFP in hippocampal dendrites. [Image: Severine Chaumont and Baljit S. Khakh, University of California, Los Angeles, USA]