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Regulating Purinergic Signals
Extracellular ATP binds to and activates P2X receptors, ligand-gated ion channels that mediate calcium influx and, consequently, various physiological and pathophysiological processes. Chaumont et al. found that the calcium-sensitive protein VILIP1 bound to P2X2 receptors under basal conditions, thereby modulating P2X2 receptor mobility and function. Both ATP application and calcium influx promoted P2X2 receptor interactions with VILIP1, which were also increased in response to stimulation of hippocampal neurons under conditions known to elicit ATP release and P2X2 receptor activation.
