BDNF Selectively Regulates GABAA Receptor Transcription by Activation of the JAK/STAT Pathway

Ingrid V. Lund; Yinghui Hu; YogendraSinh H. Raol; Rebecca S. Benham; Ramona Faris; Shelley J. Russek; Amy R. Brooks-Kayal

doi:10.1126/scisignal.1162396

Research ArticleNeuroscience

BDNF Selectively Regulates GABA_A Receptor Transcription by Activation of the JAK/STAT Pathway

Ingrid V. Lund¹,*,
Yinghui Hu³,⁴,*,
YogendraSinh H. Raol²,
Rebecca S. Benham³,⁴,
Ramona Faris⁴,⁵,
Shelley J. Russek⁴,†, and
Amy R. Brooks-Kayal⁶,⁷,†

¹Neuroscience Graduate Group and Departments of Neurology and Pediatrics, University of Pennsylvania, Philadelphia, PA 19104, USA.
²Division of Neurology, Children's Hospital, Philadelphia, PA 19104, USA.
³Program in Biomedical Neurosciences, Boston University School of Medicine, Boston, MA 02118, USA.
⁴Laboratory of Translational Epilepsy, Department of Pharmacology, Boston University School of Medicine, Boston, MA 02118, USA.
⁵Laboratory of Molecular Neurobiology, Department of Pharmacology and Experimental Therapeutics, Boston University School of Medicine, Boston, MA 02118, USA.
⁶Division of Neurology, Department of Pediatrics, University of Colorado Denver School of Medicine, Denver, CO 80045, USA.
⁷Division of Neurology, The Children's Hospital, 13123 East 16th Avenue, B155, Aurora, CO 80045, USA.

↵†To whom correspondence should be addressed. E-mail: srussek{at}bu.edu (S.J.R.) and brooks-kayal.amy{at}tchden.org (A.R.B.)

↵* These authors contributed equally to this work.

See allHide authors and affiliations

Science Signaling 14 Oct 2008:
Vol. 1, Issue 41, pp. ra9
DOI: 10.1126/scisignal.1162396

Ingrid V. Lund

1Neuroscience Graduate Group and Departments of Neurology and Pediatrics, University of Pennsylvania, Philadelphia, PA 19104, USA.

Find this author on Google Scholar
Find this author on PubMed
Search for this author on this site

Yinghui Hu

3Program in Biomedical Neurosciences, Boston University School of Medicine, Boston, MA 02118, USA.

4Laboratory of Translational Epilepsy, Department of Pharmacology, Boston University School of Medicine, Boston, MA 02118, USA.

Find this author on Google Scholar
Find this author on PubMed
Search for this author on this site

YogendraSinh H. Raol

2Division of Neurology, Children's Hospital, Philadelphia, PA 19104, USA.

Find this author on Google Scholar
Find this author on PubMed
Search for this author on this site

Rebecca S. Benham

3Program in Biomedical Neurosciences, Boston University School of Medicine, Boston, MA 02118, USA.

4Laboratory of Translational Epilepsy, Department of Pharmacology, Boston University School of Medicine, Boston, MA 02118, USA.

Find this author on Google Scholar
Find this author on PubMed
Search for this author on this site

Ramona Faris

4Laboratory of Translational Epilepsy, Department of Pharmacology, Boston University School of Medicine, Boston, MA 02118, USA.

5Laboratory of Molecular Neurobiology, Department of Pharmacology and Experimental Therapeutics, Boston University School of Medicine, Boston, MA 02118, USA.

Find this author on Google Scholar
Find this author on PubMed
Search for this author on this site

Shelley J. Russek

4Laboratory of Translational Epilepsy, Department of Pharmacology, Boston University School of Medicine, Boston, MA 02118, USA.

Find this author on Google Scholar
Find this author on PubMed
Search for this author on this site
For correspondence: srussek@bu.edu brooks-kayal.amy@tchden.org

Amy R. Brooks-Kayal

6Division of Neurology, Department of Pediatrics, University of Colorado Denver School of Medicine, Denver, CO 80045, USA.

7Division of Neurology, The Children's Hospital, 13123 East 16th Avenue, B155, Aurora, CO 80045, USA.

Find this author on Google Scholar
Find this author on PubMed
Search for this author on this site
For correspondence: srussek@bu.edu brooks-kayal.amy@tchden.org

Article
Figures & Data
Info & Metrics
eLetters
PDF

eLetters is an online forum for ongoing peer review. Submission of eLetters are open to all. Please read our Terms of Service before submitting your own eLetter.

Submit a Response to This Article

Compose eLetter

Title

Contents

More information about text formats

Plain text

Plain text
No HTML tags allowed.
Web page addresses and e-mail addresses turn into links automatically.
Lines and paragraphs break automatically.

Author Information

Contributors
First name and middle name First or given name, e.g. 'Peter'. Last Name Your last, or family, name, e.g. 'MacMoody'. Email Your email address, e.g. higgs-boson@gmail.com Role / Occupation Your role and/or occupation, e.g. 'Orthopedic Surgeon'. Affiliation Your organization or institution (if applicable), e.g. 'Royal Free Hospital'.

Statement of Competing Interests

Competing interests?

Yes

Please describe the competing interests

CAPTCHA

This question is for testing whether or not you are a human visitor and to prevent automated spam submissions.

Vertical Tabs

No eLetters have been published for this article.

View Full Text

BDNF Selectively Regulates GABA_A Receptor Transcription by Activation of the JAK/STAT Pathway

Plain text

Vertical Tabs

Science Signaling

Article Tools