Contents
Vol 1, Issue 42
Contents
Editorial Guide
- Focus Issue: From Input to Output—Are All Paths Equal?
The consequences of various input signals must first be understood to gain a systems-level explanation of signaling networks.
Research Article
- Fault Diagnosis Engineering of Digital Circuits Can Identify Vulnerable Molecules in Complex Cellular Pathways
An engineering approach reveals the weakest links in cellular signaling networks.
Perspectives
- Systems- and Molecular-Level Elucidation of Signaling Processes Through Chemistry
New techniques take advantage of chemistry to investigate signal transduction mechanisms in the cell.
- A Scaffold Makes the Switch
The location of a scaffolding protein determines whether activation of MAPK signaling in yeast will produce a graded or binary response.
- Probing Pathways Periodically
Monitoring the response to periodic input signals reveals dynamic properties of a MAPK pathway.
Editors' Choice
- Not So Homologous?
Vertebrate Hedgehog proteins bind to cell-surface proteins in a manner different from that of their Drosophila counterparts.
- Nematode Immune Defenses
In the worm C. elegans, sensory neurons surprisingly can inhibit innate immune responses, in part through the mitogen-activated protein kinase (MAPK) signaling pathway.
- MLK3 as a RhoGEF Partner
The MAPKKK MLK3 appears to interact with a Rho guanine nucleotide exchange factor to dampen Gαq signaling.
- Mapping Out Redundancy
Data from an RNAi screen combined with genetic interaction analysis allows construction of a comprehensive kinase cellular signaling network in Drosophila.
- A Complex Role for Lrp4?
Lrp4 acts as an agrin receptor that enables the agrin-dependent activation of MuSK.
- Allosteric Networks on Demand
Two allosterically regulated proteins can be engineered to interact so that when light activates one it triggers the enzymatic output (dihydrofolate reductase) of the other.
- Going Multicellular with a Beefed-Up Kinome
Bacteria that act together like a multicellular organism have a diverse set of kinases like those of eukaryotic organisms.
