Contents
Vol 1, Issue 43
Contents
Editorial Guide
- Signaling Networks and Mathematics
Biologists discover that mathematics can reveal the complexity of cellular signaling networks.
Research Article
- Essential Role of DAP12 Signaling in Macrophage Programming into a Fusion-Competent State
Signaling through the DAP12 adaptor triggers a gene expression profile that makes macrophages competent to fuse and form multinucleated giant cells.
Protocol
- High-Resolution Imaging of Redox Signaling in Live Cells Through an Oxidation-Sensitive Yellow Fluorescent Protein
Measure and visualize intracellular changes in redox state.
Journal Club
- The HIF-1α–C/EBPα Axis
Interactions between HIF-1α and C/EBPα may mediate reciprocal functional effects.
Podcast
- Science Signaling Podcast: 28 October 2008
Rune Linding explains how combining NetPhorest with a genetic screen enables researchers to gain insight into the relationships among the identified players.
Editors' Choice
- Blood Pressure Control: It’s (Another) Gas!
Hydrogen sulfide gas regulates blood pressure and blood vessel function in mice.
- Can You Hear Me Now?
Adenylyl cyclase molecules appear to shout their message to neighboring inositol 1,4,5-trisphosphate receptors.
- Scaling It Up with Retinoic Acid
Retinoic acid increases synaptic strength in a homeostatic response to inactivity through a mechanism involving localized protein synthesis.
- Preventing Seed Germination
Seed germination involves a complex interplay between gibberellic acid signaling and abscisic acid signaling that is mediated by transcriptional repressors.
- Chloride Channel Clinched
A transmembrane protein induced in cytokine-treated bronchial epithelial cells seems to be a long-sought primary carrier of a voltage- and calcium-dependent chloride current.
- Lateral Root Regulation
A membrane kinase regulates the number of stem cells in the main tip of the root as well as the de novo generation of stem cells in new laterally projecting roots.
- DNA Repair at the Edge
The damaged regions of DNA are recruited to the peripheral regions of the nucleus by a complex of nuclear-pore and ubiquitin-modifying proteins, where it is repaired.