28 October 2008
Vol 1, Issue 43
  • Contents

    • Editorial Guide

    • Research Article

    • Protocol

    • Journal Club

    • Podcast

      • Science Signaling Podcast: 28 October 2008

        Rune Linding explains how combining NetPhorest with a genetic screen enables researchers to gain insight into the relationships among the identified players.

    • Editors' Choice

      • Can You Hear Me Now?

        Adenylyl cyclase molecules appear to shout their message to neighboring inositol 1,4,5-trisphosphate receptors.

      • Scaling It Up with Retinoic Acid

        Retinoic acid increases synaptic strength in a homeostatic response to inactivity through a mechanism involving localized protein synthesis.

      • Preventing Seed Germination

        Seed germination involves a complex interplay between gibberellic acid signaling and abscisic acid signaling that is mediated by transcriptional repressors.

      • Chloride Channel Clinched

        A transmembrane protein induced in cytokine-treated bronchial epithelial cells seems to be a long-sought primary carrier of a voltage- and calcium-dependent chloride current.

      • Lateral Root Regulation

        A membrane kinase regulates the number of stem cells in the main tip of the root as well as the de novo generation of stem cells in new laterally projecting roots.

      • DNA Repair at the Edge

        The damaged regions of DNA are recruited to the peripheral regions of the nucleus by a complex of nuclear-pore and ubiquitin-modifying proteins, where it is repaired.

About The Cover

Cover image expansion

COVER This week's issue features a Research Article that shows that signaling mediated by the adaptor protein DAP12 is essential for macrophages to fuse and form multinucleated giant cells, which are a hallmark of granulomatous inflammation. The cover shows macrophages that have fused (yellow). [Image: Laura Helming, Technical University of Munich, Germany]