Contents

Contents

• Editorial Guide

  • Signaling Networks and Mathematics

    By Michael B. Yaffe

    Science Signaling28 Oct 2008 : eg7 Full AccessRestricted Access

    Biologists discover that mathematics can reveal the complexity of cellular signaling networks.

    • Abstract
    • Full Text
    • PDF

• Research Article

  • Essential Role of DAP12 Signaling in Macrophage Programming into a Fusion-Competent State

    By Laura Helming, Elena Tomasello, Themis R. Kyriakides, Fernando O. Martinez, Toshiyuki Takai, Siamon Gordon, Eric Vivier

    Science Signaling28 Oct 2008 : ra11 Full AccessRestricted Access

    Signaling through the DAP12 adaptor triggers a gene expression profile that makes macrophages competent to fuse and form multinucleated giant cells.

    • Editor's Summary
    • Abstract
    • Full Text
    • PDF

• Protocol

  • High-Resolution Imaging of Redox Signaling in Live Cells Through an Oxidation-Sensitive Yellow Fluorescent Protein

    By Giuseppe Maulucci, Valentina Labate, Marina Mele, Emiliano Panieri, Giuseppe Arcovito, Tommaso Galeotti, Henrik Østergaard, Jakob R. Winther, Marco De Spirito, Giovambattista Pani

    Science Signaling28 Oct 2008 : pl3 Full AccessRestricted Access

    Measure and visualize intracellular changes in redox state.

    • Abstract
    • Full Text
    • PDF

• Journal Club

  • The HIF-1α–C/EBPα Axis

    By Harish P. Janardhan

    Science Signaling28 Oct 2008 : jc2 Full AccessRestricted Access

    Interactions between HIF-1α and C/EBPα may mediate reciprocal functional effects.

    • Abstract
    • Full Text
    • PDF

• Podcast

  • Science Signaling Podcast: 28 October 2008

    By Rune Linding, Annalisa M. VanHook

    Science Signaling28 Oct 2008 : pc10 Full AccessRestricted Access

    Rune Linding explains how combining NetPhorest with a genetic screen enables researchers to gain insight into the relationships among the identified players.

    • Abstract
    • Full Text

• Editors' Choice

  • Blood Pressure Control: It’s (Another) Gas!

    By Paula A. Kiberstis

    Science Signaling28 Oct 2008 : ec367 Full AccessRestricted Access

    Hydrogen sulfide gas regulates blood pressure and blood vessel function in mice.

    • Abstract

  • Can You Hear Me Now?

    By L. Bryan Ray

    Science Signaling28 Oct 2008 : ec368 Full AccessRestricted Access

    Adenylyl cyclase molecules appear to shout their message to neighboring inositol 1,4,5-trisphosphate receptors.

    • Abstract

  • Scaling It Up with Retinoic Acid

    By Elizabeth M. Adler

    Science Signaling28 Oct 2008 : ec369 Full AccessRestricted Access

    Retinoic acid increases synaptic strength in a homeostatic response to inactivity through a mechanism involving localized protein synthesis.

    • Abstract

  • Preventing Seed Germination

    By Nancy R. Gough

    Science Signaling28 Oct 2008 : ec370 Full AccessRestricted Access

    Seed germination involves a complex interplay between gibberellic acid signaling and abscisic acid signaling that is mediated by transcriptional repressors.

    • Abstract

  • Chloride Channel Clinched

    By Katrina L. Kelner

    Science Signaling28 Oct 2008 : ec371 Full AccessRestricted Access

    A transmembrane protein induced in cytokine-treated bronchial epithelial cells seems to be a long-sought primary carrier of a voltage- and calcium-dependent chloride current.

    • Abstract

  • Lateral Root Regulation

    By Pamela J. Hines

    Science Signaling28 Oct 2008 : ec372 Full AccessRestricted Access

    A membrane kinase regulates the number of stem cells in the main tip of the root as well as the de novo generation of stem cells in new laterally projecting roots.

    • Abstract

  • DNA Repair at the Edge

    By Guy Riddihough

    Science Signaling28 Oct 2008 : ec373 Full AccessRestricted Access

    The damaged regions of DNA are recruited to the peripheral regions of the nucleus by a complex of nuclear-pore and ubiquitin-modifying proteins, where it is repaired.

    • Abstract