DNA Repair at the Edge

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Science Signaling  28 Oct 2008:
Vol. 1, Issue 43, pp. ec373
DOI: 10.1126/scisignal.143ec373

The nucleus of a cell can be divided into functional compartments based on transcriptional activity and DNA replication. Nagai et al. reveal a physical connection between the nuclear periphery and processes of DNA damage and repair in budding yeast. Damaged DNA, specifically collapsed replication forks and persistent double-stranded breaks, is transferred to the nuclear pores, where nuclear pore components and other proteins facilitate recombinational repair.

S. Nagai, K. Dubrana, M. Tsai-Pflugfelder, M. B. Davidson, T. M. Roberts, G. W. Brown, E. Varela, F. Hediger, S. M. Gasser, N. J. Krogan, Functional targeting of DNA damage to a nuclear pore–associated SUMO-dependent ubiquitin ligase. Science 322, 597-602 (2008). [Abstract] [Full Text]

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