11 November 2008
Vol 1, Issue 45
  • Contents

    • Research Articles

    • Podcast

    • Editors' Choice

      • A New Way to Cluster

        Endothelial cells preassemble tetraspanins and adhesion receptors in microdomains that cluster around the docking structures for adhering leukocytes.

      • Induced Pore Formation by Tetramerization

        Stim appears to trigger calcium-induced calcium release by inducing tetramerization of the pore-forming Orai subunits.

      • Inducing Endocycling

        Selective inhibition of CDK1 is sufficient to induce endoreduplication in mammalian trophoblast giant cells.

      • Stress and the RACK

        Too much stress is bad, particularly when one stress pathway inhibits function of another.

      • GSK-3β Masters TLR4 Responses

        GSK-3β inhibits the production of IFN-β by macrophages treated with LPS.

      • Reaching for the Light

        Growth of the embryonic stem in Arabidopsis thaliana is controlled by a gene that functions downstream of the circadian clock and light signaling pathways.

      • Protein Lifetimes

        A method that determines the half-lives of all cellular proteins has been used to identify targets of a ubiquitin ligase that controls the cell cycle through protein degradation.

      • Brain Repair

        Regeneration in the central nervous system is impeded by inhibitory receptors that recognize myelin-embedded proteins.

About The Cover

Cover image expansion

COVER This week's issue features a Research Article that describes how integration of protein-protein interaction networks with a human genome-wide RNAi screen leads to new insight into Wnt/β-catenin signaling. The image shows part of a protein-protein interaction network of the Wnt pathway with hits from the RNAi screen highlighted in blue and pink. [Image: Christopher Bickel, AAAS]