Contents
Vol 1, Issue 45
Contents
Research Articles
- New Regulators of Wnt/β-Catenin Signaling Revealed by Integrative Molecular Screening
Integration of protein-protein interaction networks and human genome-wide RNAi screens produces mechanistic insight into Wnt/β-catenin signaling.
- Cripto Localizes Nodal at the Limiting Membrane of Early Endosomes
Cripto facilitates ALK4 signaling by attenuating intraendosomal sorting of internalized Nodal.
Podcast
- Science Signaling Podcast: 11 November 2008
Ben Major and Randall Moon discuss their screen for cell type-specific modifiers of Wnt signaling.
Editors' Choice
- A New Way to Cluster
Endothelial cells preassemble tetraspanins and adhesion receptors in microdomains that cluster around the docking structures for adhering leukocytes.
- Induced Pore Formation by Tetramerization
Stim appears to trigger calcium-induced calcium release by inducing tetramerization of the pore-forming Orai subunits.
- Inducing Endocycling
Selective inhibition of CDK1 is sufficient to induce endoreduplication in mammalian trophoblast giant cells.
- Stress and the RACK
Too much stress is bad, particularly when one stress pathway inhibits function of another.
- GSK-3β Masters TLR4 Responses
GSK-3β inhibits the production of IFN-β by macrophages treated with LPS.
- Reproductive Competence Reduces Life Span
The reproductive system affects life span in C. elegans by regulating fat metabolism.
- Reaching for the Light
Growth of the embryonic stem in Arabidopsis thaliana is controlled by a gene that functions downstream of the circadian clock and light signaling pathways.
- Protein Lifetimes
A method that determines the half-lives of all cellular proteins has been used to identify targets of a ubiquitin ligase that controls the cell cycle through protein degradation.
- Brain Repair
Regeneration in the central nervous system is impeded by inhibitory receptors that recognize myelin-embedded proteins.
