Contents
Vol 1, Issue 46
Contents
Editorial Guide
- Focus Issue: An Expanding World for TGF-β Signaling
With new modes of regulation, and new functions for members of the pathway, TGF-β breaks the canonical barrier.
Perspectives
- Holding Their Own: The Noncanonical Roles of Smad Proteins
There are TGF-β–independent regulatory mechanisms and functions of Smads.
- PCTA: A New Player in TGF-β Signaling
The distribution of promyelocytic leukemia protein between the nucleus and cytoplasm controls Smad activation.
Editors' Choice
- Under Cover
Binding of CD3ε subunits to the plasma membrane shields critical residues from tyrosine kinases, thus preventing inadvertent T cell activation.
- Putting the Brakes on Inflammation
An endogenous inhibitor of immune cell adhesion dampens recruitment of immune cells to sites of inflammation.
- Process of Differentiation
Nuclear translocation of the intracellular domain of the Wnt receptor Ryk is required for the differentiation of neural progenitor cells into neurons.
- Starving in the Midst of Plenty
Ceramide decreases the abundance of cell surface nutrient transporters to elicit cell death.
- Surviving Lean Times
An acetylation switch controls the activity of CRTC2 in regulating the hepatic gluconeogenic program in response to fasting.
- Meaningful Fluctuations
Oscillations in MAPK activity in pheromone-stimulated yeast are linked to the formation of multiple mating projections.
- NO Switch in Lung Inflammation
S-nitrosylation of a lung surfactant protein determines whether it has pro- or anti-inflammatory effects.
- To Be or Not to Be
Positive and negative developmental signals that determine the locations of gas-exchanging leaf pores converge on a specific domain within a transcription factor.
- Ubiquitin’s Pup(py)?
A prokaryotic version of ubiquitin, a eukaryotic tag for protein degradation, is linked to lysines in prokaryotic proteins destined for destruction, a process called pupylation.
