02 December 2008
Vol 1, Issue 48
  • Contents

    • Perspective

    • Podcast

    • Editors' Choice

      • Landmine

        Intact eosinophil granules exhibit "intragranular" signaling in response to interferon-γ and the chemokine CCL11 to mediate the secretion of granule proteins.

      • An Unexpected Partner

        FGF and adenosine synergistically activate ERK, an interaction mediated through the physical association of their receptors.

      • An Upgrade in the Processor

        Activin treatment of pituitary cells increases its own production, as well as that of an opposing hormone.

      • It’s a Knock Out

        In mice, a coactivator binds to a nuclear orphan receptor and regulates glucose-6-phosphatase transcription and thus glucose homeostasis.

      • The Yin Yang of Root Regulation

        The number of stem cells in plant roots is controlled by an auxin-cytokine feedback loop in which a particular gene integrates signals from both hormones.

      • Two Inhibitors in One

        The amino-terminal domain of Wnt antagonist Dickkopf-1 functions independently of the canonical Wnt signaling pathway.

      • New Tricks for the Old PH Domain

        The pleckstrin homology domain forms a molecular switch that regulates association of an adaptor protein with the cytoskeleton.

About The Cover

Cover image expansion

COVER This week's issue features a Perspective on the possible ligand-independent activities of peroxisome proliferator–activated receptor (PPAR). The image shows a ribbon diagram of the structure of PPAR with the ligand-binding pocket indicated. [Image: Millard Lambert, GlaxoSmithKline, Research Triangle Park, NC 27709]