Contents
Vol 1, Issue 48
Contents
Perspective
- Ligand-Dependent and -Independent Regulation of PPARγ and Orphan Nuclear Receptors
It is too soon to conclude that the physiological activities of PPARγ are truly ligand-independent.
Podcast
- Science Signaling Podcast: 02 December 2008
Sam Lee and Pat Ongusaha discuss their research on the mechanisms by which ultraviolet B radiation induces cell death.
Editors' Choice
- An Unexpected Partner
FGF and adenosine synergistically activate ERK, an interaction mediated through the physical association of their receptors.
- An Upgrade in the Processor
Activin treatment of pituitary cells increases its own production, as well as that of an opposing hormone.
- It’s a Knock Out
In mice, a coactivator binds to a nuclear orphan receptor and regulates glucose-6-phosphatase transcription and thus glucose homeostasis.
- The Yin Yang of Root Regulation
The number of stem cells in plant roots is controlled by an auxin-cytokine feedback loop in which a particular gene integrates signals from both hormones.
- Two Inhibitors in One
The amino-terminal domain of Wnt antagonist Dickkopf-1 functions independently of the canonical Wnt signaling pathway.
- New Tricks for the Old PH Domain
The pleckstrin homology domain forms a molecular switch that regulates association of an adaptor protein with the cytoskeleton.
