09 December 2008
Vol 1, Issue 49
  • Contents

    • Editorial Guide

    • Research Article

    • Perspective

    • Review

    • Editors' Choice

      • From Gut to Bone

        Serotonin produced by the gut reduces bone mass.

      • Turning On TRPM3

        Pregnenolone sulphate, an endogenous steroid, directly activates the TRPM3 cation channel.

      • Toward Normalizing Metabolic Regulation

        In mice, some detrimental effects of a diet high in fat—insulin resistance, for example—result from hormonal signals sent from fat cells to the liver.

      • Geometry Influences Polarity

        Local propagation of polarity can occur in the absence of global cues provided the cells are regularly packed.

      • Follow the Leader

        One set of signaling proteins directs migration at the edge of a sheet of endothelial cells, whereas a distinct set coordinates cell movements within the sheet.

      • GSK-3, Jack of All Trades

        Cross-talk between signaling pathways alters transcriptional regulatory activity of the glucocorticoid nuclear receptor.

      • Lysyl Oxidase: A Matrix Inhibitor of TGF-β

        The amine oxidase lysyl oxidase appears to inhibit transforming growth factor–β signaling in bone through a mechanism requiring its enzymatic activity.

      • What Is Behind the Secondary Inward Current?

        Activation of a glutamate receptor in hippocampal cells leads to secondary opening of a gap junction–like channel that can contribute to seizure-like bursting.

      • Blue Light Response

        Blue light triggers the association of a photoreceptor, transcription factor, and DNA site, thus inducing expression for the gene FT (flowering time) and initiating flowering.

      • A Divisive Tale

        During cell division, a component of the spindle inhibits a small regulatory binding protein, allowing another regulator to constrict a ring between the separating daughter cells.

About The Cover

Cover image expansion

COVER This week's issue of Science Signaling complements the Science Special Issue on Organ Development. The development of plant leaves and the specialized structure called a root nodule are two of the topics highlighted in this issue. See the Editorial Guide for more details about this exciting issue. The image shows a seedling. [Image: Jupiter Images]