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Analysis of Metagene Portraits Reveals Distinct Transitions During Kidney Organogenesis

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Science Signaling  09 Dec 2008:
Vol. 1, Issue 49, pp. ra16
DOI: 10.1126/scisignal.1163630

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Revealing Kidney Formation Through Metagenes

By collecting the more than 30,000 genes into 650 groups called metagenes, Tsigelny et al. uncover genes that may orchestrate the transitions between stages of kidney development. Organization of the metagenes into self-organizing maps revealed up to eight distinct stages of kidney development. Entropy calculations of the self-organizing maps allowed the metagene-defined stages to be correlated with morphometric parameters and with specific gene networks. Genes included those already known for their involvement in kidney development as well as ones previously not implicated in this process of organogenesis, thus yielding new insight.

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