Contents
Vol 1, Issue 5
Contents
Perspective
- Metabotropic Glutamate Receptors and Fragile X Mental Retardation Protein: Partners in Translational Regulation at the Synapse
On the road to protein synthesis–dependent plasticity, FMRP is the brake and mGluRs are the gas.
Editors' Choice
- Glucose Fattens Up Muscle
Stem cells from muscle or adipose tissue form adipocytes in response to increased concentrations of glucose.
- MIFed About Metabolism
MIF acts as a local factor to activate AMP-activated protein kinase during cardiac ischemia, linking inflammation with cardiac metabolism.
- A Bioinformatics Approach to Addiction
Meta-analysis of the primary literature linking genes to addiction leads to the development of a hypothetical molecular pathway involved in addiction.
- How to Specify a Leg
Experiments reveal how similar gradients of signaling molecules specify formation of distinct spatial axes in the Drosophila leg.
- Endocannabinoid Interactions
Anandamide can inhibit the production and effects of 2-AG through activation of TRPV1.
- Monogamy in the TGF-β Receptor Relationship
Crystal structure of the transforming growth factor-β receptor I and II reveals how these members of the family restrict their ligand interactions.
- EphA2 Destabilizes Adherens Junctions
The EphA2 receptor tyrosine kinase, which is associated with tumor malignancy, disrupts cell-cell adhesion through a RhoA-dependent mechanism.
- Regulating Ovulation
In mice, a tumor suppressor commonly mutated in human cancers prevents premature activation of ovarian follicles, allowing them to form oocytes throughout life.
- T Cell Role for Cathepsin K
A lysosomal protease known to function in bone cells also operates in the innate immune pathway activated in experimental multiple sclerosis and arthritis in mice.
- Growth and Survival—The Complete Toolkit
Systematic inhibition of gene expression with RNA interference reveals genes essential for growth and survival of tumor cells, potentially leading to new cancer drugs.
- Interfering with Inflammation
Small RNAs packaged in lipid nanoparticles can be directed by antibodies to specific gut immune cells, where they suppress inflammation by inhibiting a cell-cycle protein.
