16 December 2008
Vol 1, Issue 50
  • Contents

    • Meeting Report

    • Podcast

    • Editors' Choice

      • Luminal Sensors from the Basal Side

        Basal cells extend projections that reach the luminal surface and respond to luminal hormones.

      • Vesicles to Stream By

        Migrating Dictyostelium cells leave behind vesicles containing adenylyl cyclase, creating a path of chemoattractant for other cells to follow.

      • Invariant Chain Migration Control

        By binding to a myosin, an immune-specific protein known to control antigen processing also regulates the migration of dendritic cells, possibly coordinating the two functions.

      • Cytoskeleton and Substrate Stiffness

        A model that predicts that substrate/surface stiffness acts through a cellular motor-clutch mechanism to alter retrograde flow rates and traction is confirmed in chick neurons.

      • Sensitive Fluorescence

        A FRET-based sensor enables the live monitoring of the temporal and spatial dynamics of ERK activity in cells and intact tissues.

      • Damage Control for Mitochondria

        Parkin translocates to mitochondria with low membrane potentials and causes their autophagic removal.

      • Global Influence

        FGF signaling initiates planar cell polarity during convergent extension.

      • Meiosis in the Making

        Mouse germ cells begin meiosis for sperm or egg production only when they both are stimulated by the hormone retinoic acid and express a particular RNA-binding protein.

      • Shaping Up

        The growth pattern of the plant meristem, the group of stem cells at the tip of a growing shoot, is controlled by a microtubule-based mechanical feedback loop.

      • Food for Thought

        Brain cells monitor metabolism to appropriately control blood flow according to neuronal activity and oxygen supply.

About The Cover

Cover image expansion

COVER This week's issue features a new entry in the Bioinformatics Resources section of ST NetWatch that describes a microarray data analysis tool called GEDI, the Gene Expression Dynamics Inspector. GEDI enables comparison of the expression dynamics of genes between different samples by representing clusters of genes that share expression dynamics as colored tiles on a two-dimensional mosaic. The image shows an artist's rendition of such a mosaic. Tsigelny et al. used this tool in a Research Article in the 9 December issue. [Image: Christopher Bickel, AAAS]