23 December 2008
Vol 1, Issue 51
  • Contents

    • Editorial Guide

    • Research Articles

    • Perspectives

    • Review

    • Meeting Report

    • Editors' Choice

      • Turning to the DARC Side

        The Duffy antigen receptor for chemokines promotes leukocyte migration.

      • Gender Bias

        Testosterone affects ERK2 activity, which in turn regulates the subcellular localization and activity of a lipoxygenase involved in inflammation.

      • More Estrogen, More Active

        The gonadotropin follicle-stimulating hormone both promotes production of estrogen and enhances its transcriptional activity at the ovary.

      • Slave to the Rhythm

        A simpler plant circadian clock, which normally has three interlocking feedback loops, is used in the roots, with one feedback loop regulating only a few genes.

      • Unhealthy Competition

        Cancerous immune cells create abnormal microenvironments in bone marrow that attract normal immune precursor cells, disrupting their function and exacerbating disease.

About The Cover

Cover image expansion

COVER This week's issue features a Research Article that demonstrates how the scaffold protein muscle A kinase–anchoring protein (mAKAP) regulates the stability of the transcription factor hypoxia-inducible factor 1α (HIF-1α) in a bidirectional manner. The image shows the perinuclear localization of mAKAP (in green) in neonatal rat ventricular myocytes, which were also stained for the cytoskeletal protein α-actinin (in red). [Image: Wei Wong, HHMI and Vollum Institute, Portland, OR, USA, and John D. Scott, HHMI and University of Washington School of Medicine, Seattle, WA, USA]