Contents
Vol 1, Issue 51
Contents
Editorial Guide
- Beyond Microarrays
Studies of global changes in mRNA abundance may be less than insightful.
Research Articles
- Type I IL-4Rs Selectively Activate IRS-2 to Induce Target Gene Expression in Macrophages
The ability of IL-4, but not IL-13, to efficiently activate IRS-2 leads to the expression of a subset of genes in alternatively activated macrophages.
- mAKAP Compartmentalizes Oxygen-Dependent Control of HIF-1α
The scaffold protein muscle A kinase–anchoring protein (mAKAP) regulates the stability and localization of the transcription factor HIF-1α.
Perspectives
- Bursting into the Nucleus
Calcium elicits bursts of nuclear localization of a yeast transcription factor, which may enable the coordinated activation of target genes.
- Untangling the Complex Web of IL-4– and IL-13–Mediated Signaling Pathways
Understanding how IL-4 and IL-13 signaling differ could result in the development of better anti-inflammatory therapies.
Review
- Structure and Function of the Phosphothreonine-Specific FHA Domain
The forkhead-associated (FHA) domain binds specifically to phosphothreonine residues and possesses unique structural and functional features.
Meeting Report
- Regulatory T Cells: The Cunning Fox and Its Clinical Application
A conference in Beijing, China, focused on the biology of regulatory T cells and their potential uses in treating various diseases.
Editors' Choice
- Turning to the DARC Side
The Duffy antigen receptor for chemokines promotes leukocyte migration.
- Gender Bias
Testosterone affects ERK2 activity, which in turn regulates the subcellular localization and activity of a lipoxygenase involved in inflammation.
- More Estrogen, More Active
The gonadotropin follicle-stimulating hormone both promotes production of estrogen and enhances its transcriptional activity at the ovary.
- Controlling Ectodomain Shedding from the Inside
The GTPase Rab5 acts as a cytosolic molecular switch controlling release of the ectodomain of syndecan-1 from the extracellular surface.
- Slave to the Rhythm
A simpler plant circadian clock, which normally has three interlocking feedback loops, is used in the roots, with one feedback loop regulating only a few genes.
- Unhealthy Competition
Cancerous immune cells create abnormal microenvironments in bone marrow that attract normal immune precursor cells, disrupting their function and exacerbating disease.
