05 February 2008
Vol 1, Issue 5
  • Contents

    • Perspective

    • Editors' Choice

      • Glucose Fattens Up Muscle

        Stem cells from muscle or adipose tissue form adipocytes in response to increased concentrations of glucose.

      • MIFed About Metabolism

        MIF acts as a local factor to activate AMP-activated protein kinase during cardiac ischemia, linking inflammation with cardiac metabolism.

      • A Bioinformatics Approach to Addiction

        Meta-analysis of the primary literature linking genes to addiction leads to the development of a hypothetical molecular pathway involved in addiction.

      • How to Specify a Leg

        Experiments reveal how similar gradients of signaling molecules specify formation of distinct spatial axes in the Drosophila leg.

      • Endocannabinoid Interactions

        Anandamide can inhibit the production and effects of 2-AG through activation of TRPV1.

      • Monogamy in the TGF-β Receptor Relationship

        Crystal structure of the transforming growth factor-β receptor I and II reveals how these members of the family restrict their ligand interactions.

      • EphA2 Destabilizes Adherens Junctions

        The EphA2 receptor tyrosine kinase, which is associated with tumor malignancy, disrupts cell-cell adhesion through a RhoA-dependent mechanism.

      • Regulating Ovulation

        In mice, a tumor suppressor commonly mutated in human cancers prevents premature activation of ovarian follicles, allowing them to form oocytes throughout life.

      • T Cell Role for Cathepsin K

        A lysosomal protease known to function in bone cells also operates in the innate immune pathway activated in experimental multiple sclerosis and arthritis in mice.

      • Growth and Survival—The Complete Toolkit

        Systematic inhibition of gene expression with RNA interference reveals genes essential for growth and survival of tumor cells, potentially leading to new cancer drugs.

      • Interfering with Inflammation

        Small RNAs packaged in lipid nanoparticles can be directed by antibodies to specific gut immune cells, where they suppress inflammation by inhibiting a cell-cycle protein.

About The Cover

Cover image expansion

COVER This week's issue features a Perspective on the regulation of protein translation at the synapse by fragile X mental retardation protein (FMRP). The image depicts FMRP (in gray) binding to its target mRNA. [Image: Christopher Bickel, AAAS]