12 February 2008
Vol 1, Issue 6
  • Contents

    • Perspectives

    • Editors' Choice

      • A BAD Role in Insulin Release

        The BH3 domain of the Bcl-2 family member BAD interacts with glucokinase to contribute to glucose-mediated stimulation of insulin release.

      • The Stress of Aging

        A role for the JunD transcription factor in sustaining longevity is proposed.

      • Who Stole the Chemokine?

        Chemokine receptor CXCR7 helps primordial germ cell migration by sequestering a distracting chemokine.

      • Competing for ROCK1

        PDK1 and RhoE compete for ROCK1, with PDK1 preventing inhibition by RhoE.

      • Capturing Kinase Substrates

        A new approach allows the capture and release of substrates of a specific kinase.

      • Tipping the Balance in T Cell Decisions

        A key cell fate decision--to become a cytotoxic rather than a helper T cell--is controlled by repression of the helper T cell transcription factor by a second transcription factor.

      • Mixed-Up Microflora

        A Drosophila gene important in development also inhibits the production of harmful antimicrobial peptides that could kill off beneficial gut microbes.

      • Specifying Gene Expression

        For certain genes regulated by the nucleosome-binding protein PARP-1, the presence of a linker histone at the promoter prevents PARP-1 binding, inhibiting gene activation.

About The Cover

Cover image expansion

COVER This week's issue features a Perspective on the secretion from antigen-presenting cells (APCs) of vesicles (exosomes) that contain immunostimulatory molecules. The image depicts an APC as it produces exosomes, some of which can stimulate a bystander T cell. [Image: Christopher Bickel, AAAS]