Contents
Vol 1, Issue 6
Contents
Perspectives
- Novel Roles for the NF-κB Signaling Pathway in Regulating Neuronal Function
Components of the NF-κB pathway may use multiple mechanisms to influence synaptic plasticity, learning, and memory.
- Exosomes Secreted by Bacterially Infected Macrophages Are Proinflammatory
The release of bacterial components in vesicles secreted by infected macrophages helps promote inflammation.
Editors' Choice
- A BAD Role in Insulin Release
The BH3 domain of the Bcl-2 family member BAD interacts with glucokinase to contribute to glucose-mediated stimulation of insulin release.
- The Stress of Aging
A role for the JunD transcription factor in sustaining longevity is proposed.
- Who Stole the Chemokine?
Chemokine receptor CXCR7 helps primordial germ cell migration by sequestering a distracting chemokine.
- Competing for ROCK1
PDK1 and RhoE compete for ROCK1, with PDK1 preventing inhibition by RhoE.
- Capturing Kinase Substrates
A new approach allows the capture and release of substrates of a specific kinase.
- Tipping the Balance in T Cell Decisions
A key cell fate decision--to become a cytotoxic rather than a helper T cell--is controlled by repression of the helper T cell transcription factor by a second transcription factor.
- Mixed-Up Microflora
A Drosophila gene important in development also inhibits the production of harmful antimicrobial peptides that could kill off beneficial gut microbes.
- Specifying Gene Expression
For certain genes regulated by the nucleosome-binding protein PARP-1, the presence of a linker histone at the promoter prevents PARP-1 binding, inhibiting gene activation.
