Contents
Vol 1, Issue 8
Contents
Perspectives
- Context-Dependent Activation or Inhibition of Wnt-β-Catenin Signaling by Kremen
The effect of Kremen 2 on Wnt signaling depends on the presence or absence of the Wnt antagonist Dickkopf1.
- A Cytoskeletal Platform for Local Translation in Axons
Mutual interactions between the cytoskeleton and local translation may mediate growth cone steering response.
Editors' Choice
- Looks Like a Protease, Walks Like a Protease…
Two new roles for the protease activity of MALT1 in T cell activation are revealed.
- Turning off TLR
Long-term desensitization of the innate immune response may make individuals more susceptible to secondary infection.
- Recruited Resistance
Recruitment of O-GlcNAc transferase to the plasma membrane, which is mediated by PI(3,4,5)P3, inhibits insulin receptor signaling.
- No Role for HIF?
The transcriptional coactivator PGC-1α triggers neovascularization in response to ischemia through a HIF-1α-independent, ERR-α-dependent mechanism.
- Cycling on with Decreased Mitochondrial Function
Selective loss of erythroid Rb leads to decreased mitochondrial biogenesis and ineffective erythrocyte maturation.
- Connecting Wnt to the Cytoskeleton
WGEF is a guanine nucleotide exchange factor in the planar cell polarity pathway.
- Tagging + Recruitment = Learning
Mushroom-shaped synaptic spines activated during learning preferentially capture newly synthesized glutamate receptors, which may contribute to memory storage.
- Regulating the Regulon
The structure of a repressor-activator complex for galactose metabolism shows that its assembly is controlled by the ratio of two cofactors that reflect the cell’s metabolism.
- Tau and Microtubule Motors
When molecular motors move along microtubules, they encounter the bound protein tau; the dynein motor then reverses direction, whereas the kinesin motor detaches.
