26 February 2008
Vol 1, Issue 8
  • Contents

    • Perspectives

    • Editors' Choice

      • Turning off TLR

        Long-term desensitization of the innate immune response may make individuals more susceptible to secondary infection.

      • Recruited Resistance

        Recruitment of O-GlcNAc transferase to the plasma membrane, which is mediated by PI(3,4,5)P3, inhibits insulin receptor signaling.

      • No Role for HIF?

        The transcriptional coactivator PGC-1α triggers neovascularization in response to ischemia through a HIF-1α-independent, ERR-α-dependent mechanism.

      • Tagging + Recruitment = Learning

        Mushroom-shaped synaptic spines activated during learning preferentially capture newly synthesized glutamate receptors, which may contribute to memory storage.

      • Regulating the Regulon

        The structure of a repressor-activator complex for galactose metabolism shows that its assembly is controlled by the ratio of two cofactors that reflect the cell’s metabolism.

      • Tau and Microtubule Motors

        When molecular motors move along microtubules, they encounter the bound protein tau; the dynein motor then reverses direction, whereas the kinesin motor detaches.

About The Cover

Cover image expansion

COVER This week's issue features a Perspective on how the presence of the Wnt antagonist Dickkopf1 (Dkk1) determines whether Kremens proteins will either inhibit or stimulate Wnt signaling. The image shows Kremen (in green) with Dkk1 (in blue) internalizing the Wnt co-receptor LRP6 (in red), thus dissociating LRP6 from the Wnt receptor Frizzled at the plasma membrane. [Image: Christopher Bickel, AAAS]