04 March 2008
Vol 1, Issue 9
  • Contents

    • Meeting Report

    • Teaching Resource

    • Editors' Choice

      • Channel Talk

        Two neuronal channel proteins interact and alter each other’s function.

      • Pulling on the TCR

        In vitro experiments suggest that mechanical stress of the APC-T cell interaction is critical for T cell receptor activation.

      • Translating GAGs to Regulate Morphogens

        BMP signaling early in Drosophila embryogenesis escapes HSPG regulation because of a translational block of GAG synthesis.

      • Targeted Effects

        β-catenin in muscle fibers, but not in motoneurons, is necessary for presynaptic neurotransmitter release in the neuromuscular junction.

      • Preventing Interaction with the Proteasome

        Phosphorylation of the coactivator SRC-3 by atypical protein kinase C blocks the interaction of SRC-3 with the proteasome.

      • Extracellular Calcium Matters, Too

        The extracellular calcium-sensing receptor (CaSR) is important for neurite outgrowth and branching.

      • Memory Breakdown

        Upon recollection, mouse memories of fearful situations become labile, as postsynaptic proteins are degraded by proteasomes and are then reconsolidated via protein synthesis.

      • Fruit Flies, Mosquitoes, and CO2 Sensations

        Loss of a microRNA in Drosophila leads to misexpression of CO2-sensing neurons in the maxillary palps, an arrangement that is a hybrid between that of the fruit fly and the mosquito.

      • Explaining Polarized Growth Patterns

        Accumulation of an oxidase enzyme at one end of Arabidopsis root hair cells generates reactive oxygen species, which in turn trigger calcium entry and directional growth.

      • Dissecting Function in the Living Brain

        Blockade of neural activity in the CA3 region of the hippocampus with a reversible, inducible transgenic method inhibits rapid learning but spares certain spatial tasks.

About The Cover

Cover image expansion

COVER This week's issue features a Meeting Report on the 3rd International Conference on cGMP Generators, Effectors and Therapeutic Implications, which focused on the mechanisms and therapeutic potential of the cGMP signaling system. The image shows cGMP and is derived from the PDB entry 1Q3E. [Image: Christopher Bickel, AAAS]