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vol. 10 no. 460
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History:
- Received June 22, 2016
- Accepted November 30, 2016
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Copyright © 2017, American Association for the Advancement of Science
Research ArticleMetabolism
The SCFβ-TRCP E3 ubiquitin ligase complex targets Lipin1 for ubiquitination and degradation to promote hepatic lipogenesis
- View ORCID ProfileKouhei Shimizu1,2,*,
- Hidefumi Fukushima2,*,
- Kohei Ogura1,3,
- Evan C. Lien1,
- Naoe Taira Nihira1,
- Jinfang Zhang1,
- Brian J. North1,
- Ailan Guo4,
- Katsuyuki Nagashima5,
- Tadashi Nakagawa6,
- Seira Hoshikawa2,7,
- Asami Watahiki2,
- Koji Okabe5,
- Aya Yamada7,
- Alex Toker1,
- John M. Asara8,
- Satoshi Fukumoto2,7,
- Keiichi I. Nakayama9,
- Keiko Nakayama6,
- View ORCID ProfileHiroyuki Inuzuka1,2,†, and
- View ORCID ProfileWenyi Wei1,†
- 1Department of Pathology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215, USA.
- 2Center for Advanced Stem Cell and Regenerative Research, Tohoku University Graduate School of Dentistry, Sendai 980-8575, Japan.
- 3Department of Infectious Diseases, National Center for Global Health and Medicine, Tokyo 162-8655, Japan.
- 4Cell Signaling Technology Inc., Danvers, MA 01923, USA.
- 5Department of Physiological Science and Molecular Biology, Fukuoka Dental College, Fukuoka 814-0193, Japan.
- 6Division of Cell Proliferation, United Centers for Advanced Research and Translational Medicine, Tohoku University Graduate School of Medicine, Sendai 980-8575, Japan.
- 7Division of Pediatric Dentistry, Department of Oral Health and Development Sciences, Tohoku University Graduate School of Dentistry, Sendai 980-8575, Japan.
- 8Division of Signal Transduction, Beth Israel Deaconess Medical Center and Department of Medicine, Harvard Medical School, Boston, MA 02115, USA.
- 9Division of Cell Regulation Systems, Medical Institute of Bioregulation, Kyushu University, Fukuoka 812-8582, Japan.
- ↵†Corresponding author. Email: hinuzuka{at}bidmc.harvard.edu (H.I.); wwei2{at}bidmc.harvard.edu (W.W.)
↵* These authors contributed equally to this work.
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Science Signaling 03 Jan 2017:
Vol. 10, Issue 460, eaah4117
DOI: 10.1126/scisignal.aah4117
Vol. 10, Issue 460, eaah4117
DOI: 10.1126/scisignal.aah4117
Kouhei Shimizu
1Department of Pathology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215, USA.
2Center for Advanced Stem Cell and Regenerative Research, Tohoku University Graduate School of Dentistry, Sendai 980-8575, Japan.
Hidefumi Fukushima
2Center for Advanced Stem Cell and Regenerative Research, Tohoku University Graduate School of Dentistry, Sendai 980-8575, Japan.
Kohei Ogura
1Department of Pathology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215, USA.
3Department of Infectious Diseases, National Center for Global Health and Medicine, Tokyo 162-8655, Japan.
Evan C. Lien
1Department of Pathology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215, USA.
Naoe Taira Nihira
1Department of Pathology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215, USA.
Jinfang Zhang
1Department of Pathology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215, USA.
Brian J. North
1Department of Pathology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215, USA.
Ailan Guo
4Cell Signaling Technology Inc., Danvers, MA 01923, USA.
Katsuyuki Nagashima
5Department of Physiological Science and Molecular Biology, Fukuoka Dental College, Fukuoka 814-0193, Japan.
Tadashi Nakagawa
6Division of Cell Proliferation, United Centers for Advanced Research and Translational Medicine, Tohoku University Graduate School of Medicine, Sendai 980-8575, Japan.
Seira Hoshikawa
2Center for Advanced Stem Cell and Regenerative Research, Tohoku University Graduate School of Dentistry, Sendai 980-8575, Japan.
7Division of Pediatric Dentistry, Department of Oral Health and Development Sciences, Tohoku University Graduate School of Dentistry, Sendai 980-8575, Japan.
Asami Watahiki
2Center for Advanced Stem Cell and Regenerative Research, Tohoku University Graduate School of Dentistry, Sendai 980-8575, Japan.
Koji Okabe
5Department of Physiological Science and Molecular Biology, Fukuoka Dental College, Fukuoka 814-0193, Japan.
Aya Yamada
7Division of Pediatric Dentistry, Department of Oral Health and Development Sciences, Tohoku University Graduate School of Dentistry, Sendai 980-8575, Japan.
Alex Toker
1Department of Pathology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215, USA.
John M. Asara
8Division of Signal Transduction, Beth Israel Deaconess Medical Center and Department of Medicine, Harvard Medical School, Boston, MA 02115, USA.
Satoshi Fukumoto
2Center for Advanced Stem Cell and Regenerative Research, Tohoku University Graduate School of Dentistry, Sendai 980-8575, Japan.
7Division of Pediatric Dentistry, Department of Oral Health and Development Sciences, Tohoku University Graduate School of Dentistry, Sendai 980-8575, Japan.
Keiichi I. Nakayama
9Division of Cell Regulation Systems, Medical Institute of Bioregulation, Kyushu University, Fukuoka 812-8582, Japan.
Keiko Nakayama
6Division of Cell Proliferation, United Centers for Advanced Research and Translational Medicine, Tohoku University Graduate School of Medicine, Sendai 980-8575, Japan.
Hiroyuki Inuzuka
1Department of Pathology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215, USA.
2Center for Advanced Stem Cell and Regenerative Research, Tohoku University Graduate School of Dentistry, Sendai 980-8575, Japan.
Wenyi Wei
1Department of Pathology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215, USA.
