Papers of note in Science 354 (6319)

Annalisa M. VanHook

doi:10.1126/scisignal.aam6503

This week’s articles highlight the development of hair and sweat glands in human skin, how calcium signals affect the sensitivity of a mouse’s whiskers, peptide hormone processing in plants, and conformational changes that enable bacteriorhodopsin to harvest energy from light.

DEVELOPMENT

How to grow hair or sweat glands

Mice and humans exploit the epithelial-mesenchymal circuitry in different ways to direct sweat gland or hair follicle generation.

NEUROSCIENCE

Now you feel it, now you don't

The threshold for perception is increased upon down-regulation of dendritic activity.

PLANT BIOLOGY

Prohormone processing by subtilases

Redundant proteases mediate the formation of a peptide signal for the abscission of floral organs in Arabidopsis.

STRUCTURAL BIOLOGY

Snapshots of bacteriorhodopsin

Time-resolved serial crystallography using an x-ray free electron laser reveals structural changes in bacteriorhodopsin.

Highlighted Articles

1. C. P. Lu,
2. L. Polak,
3. B. E. Keyes,
4. E. Fuchs
, Spatiotemporal antagonism in mesenchymal-epithelial signaling in sweat versus hair fate decision. Science 354, aah6102 (2016).
1. Y. C. Lai,
2. C.-M. Chuong
, The “tao” of integuments. Science 354, 1533–1534 (2016).
1. N. Takahashi,
2. T. G. Oertner,
3. P. Hegemann,
4. M. E. Larkum
, Active cortical dendrites modulate perception. Science 354, 1587–1590 (2016).
1. K. Schardon,
2. M. Hohl,
3. L. Graff,
4. J. Pfannstiel,
5. W. Schulze,
6. A. Stintzi,
7. A. Schaller
, Precursor processing for plant peptide hormone maturation by subtilisin-like serine proteinases. Science 354, 1594–1597 (2016).
1. E. Nango,
2. A. Royant,
3. M. Kubo,
4. T. Nakane,
5. C. Wickstrand,
6. T. Kimura,
7. T. Tanaka,
8. K. Tono,
9. C. Song,
10. R. Tanaka,
11. T. Arima,
12. A. Yamashita,
13. J. Kobayashi,
14. T. Hosaka,
15. E. Mizohata,
16. P. Nogly,
17. M. Sugahara,
18. D. Nam,
19. T. Nomura,
20. T. Shimamura,
21. D. Im,
22. T. Fujiwara,
23. Y. Yamanaka,
24. B. Jeon,
25. T. Nishizawa,
26. K. Oda,
27. M. Fukuda,
28. R. Andersson,
29. P. Båth,
30. R. Dods,
31. J. Davidsson,
32. S. Matsuoka,
33. S. Kawatake,
34. M. Murata,
35. O. Nureki,
36. S. Owada,
37. T. Kameshima,
38. T. Hatsui,
39. Y. Joti,
40. G. Schertler,
41. M. Yabashi,
42. A.-N. Bondar,
43. J. Standfuss,
44. R. Neutze,
45. S. Iwata
, A three-dimensional movie of structural changes in bacteriorhodopsin. Science 354, 1552–1557 (2016).

View Abstract

[1] C. P. Lu,
L. Polak,
B. E. Keyes,
E. Fuchs
, Spatiotemporal antagonism in mesenchymal-epithelial signaling in sweat versus hair fate decision. Science 354, aah6102 (2016).

[2] C. P. Lu,

[3] L. Polak,

[4] B. E. Keyes,

[5] E. Fuchs

[6] Y. C. Lai,
C.-M. Chuong
, The “tao” of integuments. Science 354, 1533–1534 (2016).

[7] Y. C. Lai,

[8] C.-M. Chuong

[9] N. Takahashi,
T. G. Oertner,
P. Hegemann,
M. E. Larkum
, Active cortical dendrites modulate perception. Science 354, 1587–1590 (2016).

[10] N. Takahashi,

[11] T. G. Oertner,

[12] P. Hegemann,

[13] M. E. Larkum

[14] K. Schardon,
M. Hohl,
L. Graff,
J. Pfannstiel,
W. Schulze,
A. Stintzi,
A. Schaller
, Precursor processing for plant peptide hormone maturation by subtilisin-like serine proteinases. Science 354, 1594–1597 (2016).

[15] K. Schardon,

[16] M. Hohl,

[17] L. Graff,

[18] J. Pfannstiel,

[19] W. Schulze,

[20] A. Stintzi,

[21] A. Schaller

[22] E. Nango,
A. Royant,
M. Kubo,
T. Nakane,
C. Wickstrand,
T. Kimura,
T. Tanaka,
K. Tono,
C. Song,
R. Tanaka,
T. Arima,
A. Yamashita,
J. Kobayashi,
T. Hosaka,
E. Mizohata,
P. Nogly,
M. Sugahara,
D. Nam,
T. Nomura,
T. Shimamura,
D. Im,
T. Fujiwara,
Y. Yamanaka,
B. Jeon,
T. Nishizawa,
K. Oda,
M. Fukuda,
R. Andersson,
P. Båth,
R. Dods,
J. Davidsson,
S. Matsuoka,
S. Kawatake,
M. Murata,
O. Nureki,
S. Owada,
T. Kameshima,
T. Hatsui,
Y. Joti,
G. Schertler,
M. Yabashi,
A.-N. Bondar,
J. Standfuss,
R. Neutze,
S. Iwata
, A three-dimensional movie of structural changes in bacteriorhodopsin. Science 354, 1552–1557 (2016).

[23] E. Nango,

[24] A. Royant,

[25] M. Kubo,

[26] T. Nakane,

[27] C. Wickstrand,

[28] T. Kimura,

[29] T. Tanaka,

[30] K. Tono,

[31] C. Song,

[32] R. Tanaka,

[33] T. Arima,

[34] A. Yamashita,

[35] J. Kobayashi,

[36] T. Hosaka,

[37] E. Mizohata,

[38] P. Nogly,

[39] M. Sugahara,

[40] D. Nam,

[41] T. Nomura,

[42] T. Shimamura,

[43] D. Im,

[44] T. Fujiwara,

[45] Y. Yamanaka,

[46] B. Jeon,

[47] T. Nishizawa,

[48] K. Oda,

[49] M. Fukuda,

[50] R. Andersson,

[51] P. Båth,

[52] R. Dods,

[53] J. Davidsson,

[54] S. Matsuoka,

[55] S. Kawatake,

[56] M. Murata,

[57] O. Nureki,

[58] S. Owada,

[59] T. Kameshima,

[60] T. Hatsui,

[61] Y. Joti,

[62] G. Schertler,

[63] M. Yabashi,

[64] A.-N. Bondar,

[65] J. Standfuss,

[66] R. Neutze,

[67] S. Iwata

Papers of note in Science 354 (6319)

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