Contents
10 January 2017
Vol 10, Issue 461
Vol 10, Issue 461
Research Articles
- Reduced abundance of the E3 ubiquitin ligase E6AP contributes to decreased expression of the INK4/ARF locus in non–small cell lung cancer
E6AP exhibits tumor suppressor activity that may help stratify NSCLC patients.
- Autocrine Wnt regulates the survival and genomic stability of embryonic stem cells
Wnt signaling ensures proper chromosome segregation and genomic stability in proliferating embryonic stem cells.
- Synergistic regulation of serotonin and opioid signaling contributes to pain insensitivity in Nav1.7 knockout mice
The voltage-gated Na+ channel Nav1.7 controls the balance of pain-promoting and pain-relieving receptor input.
- Signaling by two-component system noncognate partners promotes intrinsic tolerance to polymyxin B in uropathogenic Escherichia coli
A single stimulus triggers cross talk between two signaling systems that promotes antibiotic resistance in uropathogenic Escherichia coli.
Editors Choice
- Tumors block pain with CXCL12
The chemokine CXCL12 released from early stage pancreatic cancer recruits Schwann cells and suppresses pain signaling.
- New connections: NHERF gates activity
The NHERF molecular adaptors serve as gates for TRPC4 and TRPC5 regulation by diacylglycerol and recognition of CFTR by the quality control checkpoint.
- Papers of note in Science 355 (6320)
This week’s articles demonstrate that prostate cancer cells become resistant to androgen-deprivation therapy by changing their identity.
- Papers of note in Science Translational Medicine 9 (371)
This week’s articles show that targeting the receptor PAR4 may be a safe antiplatelet agent and that a live cell–based therapy stimulates wound healing in leg ulcers.
- Papers of note in Nature 541 (7635)
This week’s articles show how targeting a fatty acid receptor blocks metastasis, reveal the structural basis for the mechanism of action of a potassium channel, and indicate that splicing factor 1 is required for life span extension in worms.
About The Cover
Online Cover This week features a Research Article that describes how Wnt signaling ensures proper chromosome segregation and genomic stability in proliferating embryonic stem cells. The image shows an embryonic stem cell with a lagging chromosome (center), a phenomenon that contributes to aberrant chromosome segregation and occurs with loss of Wnt signaling. [Image: Iris Augustin/German Cancer Research Center (DKFZ) and Heidelberg University, Heidelberg, Germany]