Papers of note in Nature 541 (7635)

John F. Foley

doi:10.1126/scisignal.aam7182

This week’s articles show how targeting a fatty acid receptor blocks metastasis, reveal the structural basis for the mechanism of action of a potassium channel, and indicate that splicing factor 1 is required for life span extension in worms.

CANCER

Inhibiting metastasis by blocking CD36

Pascual et al. show that cancer cells with a high abundance of the fatty acid receptor CD36 inititate metastasis, which can be inhibited by blockade of the receptor.

STRUCTURAL BIOLOGY

Solving the structure of Slo1

Tao et al. and Hite et al. present full-length, high-resolution structures of the calcium-activated potassium channel Slo1.

PHYSIOLOGY

Extending lifespan in worms

Heintz et al. show that splicing factor 1 is required for the extension of life span in Caenorhabditis elegans by dietary restriction and the modulation of TORC1 signaling components.

Highlighted Articles

1. G. Pascual,
2. A. Avgustinova,
3. S. Mejetta,
4. M. Martín,
5. A. Castellanos,
6. C. S.-O. Attolini,
7. A. Berenguer,
8. N. Prats,
9. A. Toll,
10. J. A. Hueto,
11. C. Bescós,
12. L. Di Croce,
13. S. A. Benitah
, Targeting metastasis-initiating cells through the fatty acid receptor CD36. Nature 541, 41–45 (2017).
OpenUrl
1. X. Tao,
2. R. K. Hite,
3. R. MacKinnon
, Cryo-EM structure of the open high-conductance Ca(²⁺)-activated K(⁺) channel. Nature 541, 46–51 (2017).
OpenUrl
1. R. K. Hite,
2. X. Tao,
3. R. MacKinnon
, Structural basis for gating the high-conductance Ca(²⁺)-activated K(⁺) channel. Nature 541, 52–57 (2017).
OpenUrl
1. K. L. Magleby
, Structural biology: Ion-channel mechanisms revealed. Nature 541, 33–34 (2017).
OpenUrl
1. C. Heintz,
2. T. K. Doktor,
3. A. Lanjuin,
4. C. C. Escoubas,
5. Y. Zhang,
6. H. J. Weir,
7. S. Dutta,
8. C. G. Silva-García,
9. G. H. Bruun,
10. I. Morantte,
11. G. Hoxhaj,
12. B. D. Manning,
13. B. S. Andresen,
14. W. B. Mair
, Splicing factor 1 modulates dietary restriction and TORC1 pathway longevity in C. elegans. Nature 541, 102–106 (2017).
OpenUrl

View Abstract

[1] G. Pascual,
A. Avgustinova,
S. Mejetta,
M. Martín,
A. Castellanos,
C. S.-O. Attolini,
A. Berenguer,
N. Prats,
A. Toll,
J. A. Hueto,
C. Bescós,
L. Di Croce,
S. A. Benitah
, Targeting metastasis-initiating cells through the fatty acid receptor CD36. Nature 541, 41–45 (2017).
OpenUrl

[2] G. Pascual,

[3] A. Avgustinova,

[4] S. Mejetta,

[5] M. Martín,

[6] A. Castellanos,

[7] C. S.-O. Attolini,

[8] A. Berenguer,

[9] N. Prats,

[10] A. Toll,

[11] J. A. Hueto,

[12] C. Bescós,

[13] L. Di Croce,

[14] S. A. Benitah

[15] X. Tao,
R. K. Hite,
R. MacKinnon
, Cryo-EM structure of the open high-conductance Ca(²⁺)-activated K(⁺) channel. Nature 541, 46–51 (2017).
OpenUrl

[16] X. Tao,

[17] R. K. Hite,

[18] R. MacKinnon

[19] R. K. Hite,
X. Tao,
R. MacKinnon
, Structural basis for gating the high-conductance Ca(²⁺)-activated K(⁺) channel. Nature 541, 52–57 (2017).
OpenUrl

[20] R. K. Hite,

[21] X. Tao,

[22] R. MacKinnon

[23] K. L. Magleby
, Structural biology: Ion-channel mechanisms revealed. Nature 541, 33–34 (2017).
OpenUrl

[24] K. L. Magleby

[25] C. Heintz,
T. K. Doktor,
A. Lanjuin,
C. C. Escoubas,
Y. Zhang,
H. J. Weir,
S. Dutta,
C. G. Silva-García,
G. H. Bruun,
I. Morantte,
G. Hoxhaj,
B. D. Manning,
B. S. Andresen,
W. B. Mair
, Splicing factor 1 modulates dietary restriction and TORC1 pathway longevity in C. elegans. Nature 541, 102–106 (2017).
OpenUrl

[26] C. Heintz,

[27] T. K. Doktor,

[28] A. Lanjuin,

[29] C. C. Escoubas,

[30] Y. Zhang,

[31] H. J. Weir,

[32] S. Dutta,

[33] C. G. Silva-García,

[34] G. H. Bruun,

[35] I. Morantte,

[36] G. Hoxhaj,

[37] B. D. Manning,

[38] B. S. Andresen,

[39] W. B. Mair

Papers of note in Nature 541 (7635)

Highlighted Articles

Sci. Signal.

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