Editors' ChoiceMEDICINE

Papers of note in Science Translational Medicine 9 (372)

See allHide authors and affiliations

Science Signaling  17 Jan 2017:
Vol. 10, Issue 462, eaam7597
DOI: 10.1126/scisignal.aam7597

This week’s papers describe new therapeutic avenues to kill tumor-initiating cells in breast, ovarian, and lung cancer patients; mitigate graft-versus-host disease after hematopoietic cell transplants in leukemia patients; and stimulate bone healing in diabetic patients.


Guiding T cells to stem GVHD

Betts et al. show that inhibiting Aurora kinase A and JAK2 signal transduction pathways permits the differentiation of potent regulatory T cells while neutralizing alloreactive T cells and preventing graft-versus-host disease without impairing antitumor responses.


Stem cells: The key to boosting bone healing in diabetes

Tevlin et al. show that local delivery of a missing growth factor to the skeletal stem cell niche restores bone healing in diabetic mice.


Initiating an antitumor attack

Damelin et al. report that PTK7 is a tumor-initiating cell antigen, which can be targeted with an antibody-drug conjugate to confer sustained tumor regressions.

Highlighted Articles

Stay Connected to Science Signaling

Navigate This Article