This week’s papers describe therapies for myeloid cancers and a kinase to inhibit in order to prevent pathogenic bone destruction.
BONE DEGENERATION
A new way to resorb bone
Andrade et al. report that inhibition of RON kinase prevents pathogenic bone destruction in mouse models and a human clinical study.
CANCER
Stemming the tide of leukemia development
Chung et al. show that CD99 is a potential therapeutic target enriched on disease stem cells in myeloid malignancies.
CAR sharing
Qasim et al. report that universal gene-edited CAR19 T cells eliminate infant leukemia.
