Editors' ChoiceCellular and Molecular Signaling

Papers of note in Science 355 (6323)

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Science Signaling  31 Jan 2017:
Vol. 10, Issue 464, eaam8641
DOI: 10.1126/scisignal.aam8641

This week's articles include new research about how dengue virus can deplete platelets; a distinct N-end rule pathway for turnover of gluconeogenic enzymes in yeast; and the involvement of SUMO, ubiquitin, and the proteasome in meiotic recombination.


A rare ability to enhance dengue virus disease

Wang et al. implicate immunoglobulin subclass IgG1, which lacks fucosyl residues, in severe dengue disease during secondary infections.


How to remove unnecessary enzymes

Chen et al. found that Gid4 is the Pro/N-recognin of a Pro/N-end rule pathway in yeast that targets N-terminal proline and adjacent motifs.


Proteasomes and SUMO wrestle chromosomes

Ahuja et al. report that the cellular proteostasis machinery helps direct chromosome pairing and recombination during germ cell division (see also Zetka).

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