Papers of note in Nature 541 (7638)

Annalisa M. VanHook

doi:10.1126/scisignal.aam8650

This week’s articles are about peptides that mediate communication between viruses, how microglia induce reactive astrocytes that contribute to neuronal cell death, and how kinases of the Hippo pathway influence breast cell fate.

MICROBIOLOGY

Communication between viruses

Erez et al. identified virus-encoded peptides that are secreted by infected cells and mediate communication between viruses (see commentary by Davidson).

NEUROSCIENCE

Inducing neurotoxic reactive astrocytes

Liddelow et al. found that cytokines secreted by microglia induce a subtype of reactive astrocytes that contribute to the death of neurons in mice and are associated with neurodegenerative disorders in humans.

DEVELOPMENTAL BIOLOGY

Hippo pathway kinases and breast cell fate

Britschgi et al. report that kinases of the Hippo pathway influence breast cell fate by promoting the degradation of estrogen receptor-α.

Highlighted Articles

1. Z. Erez,
2. I. Steinberger-Levy,
3. M. Shamir,
4. S. Doron,
5. A. Stokar-Avihail,
6. Y. Peleg,
7. S. Melamed,
8. A. Leavitt,
9. A. Savidor,
10. S. Albeck,
11. G. Amitai,
12. R. Sorek
, Communication between viruses guides lysis–lysogeny decisions. Nature 541, 488–493 (2017).
OpenUrl
1. A. R. Davidson
, Virology: Phages make a group decision. Nature 541, 466–467 (2017).
OpenUrl
1. S. A. Liddelow,
2. K. A. Guttenplan,
3. L. E. Clarke,
4. F. C. Bennett,
5. C. J. Bohlen,
6. L. Schirmer,
7. M. L. Bennett,
8. A. E. Münch,
9. W.-S. Chung,
10. T. C. Peterson,
11. D. K. Wilton,
12. A. Frouin,
13. B. A. Napier,
14. N. Panicker,
15. M. Kumar,
16. M. S. Buckwalter,
17. D. H. Rowitch,
18. V. L. Dawson,
19. T. M. Dawson,
20. B. Stevens,
21. B. A. Barres
, Neurotoxic reactive astrocytes are induced by activated microglia. Nature 541, 481–487 (2017).
OpenUrl
1. A. Britschgi,
2. S. Duss,
3. S. Kim,
4. J. P. Couto,
5. H. Brinkhaus,
6. S. Koren,
7. D. De Silva,
8. K. D. Mertz,
9. D. Kaup,
10. Z. Varga,
11. H. Voshol,
12. A. Vissieres,
13. C. Leroy,
14. T. Roloff,
15. M. B. Stadler,
16. C. H. Scheel,
17. L. J. Miraglia,
18. A. P. Orth,
19. G. M. C. Bonamy,
20. V. A. Reddy,
21. M. Bentires-Alj
, The Hippo kinases LATS1 and 2 control human breast cell fate via crosstalk with ERα. Nature 541, 541–545 (2017).
OpenUrl

View Abstract

[1] Z. Erez,
I. Steinberger-Levy,
M. Shamir,
S. Doron,
A. Stokar-Avihail,
Y. Peleg,
S. Melamed,
A. Leavitt,
A. Savidor,
S. Albeck,
G. Amitai,
R. Sorek
, Communication between viruses guides lysis–lysogeny decisions. Nature 541, 488–493 (2017).
OpenUrl

[2] Z. Erez,

[3] I. Steinberger-Levy,

[4] M. Shamir,

[5] S. Doron,

[6] A. Stokar-Avihail,

[7] Y. Peleg,

[8] S. Melamed,

[9] A. Leavitt,

[10] A. Savidor,

[11] S. Albeck,

[12] G. Amitai,

[13] R. Sorek

[14] A. R. Davidson
, Virology: Phages make a group decision. Nature 541, 466–467 (2017).
OpenUrl

[15] A. R. Davidson

[16] S. A. Liddelow,
K. A. Guttenplan,
L. E. Clarke,
F. C. Bennett,
C. J. Bohlen,
L. Schirmer,
M. L. Bennett,
A. E. Münch,
W.-S. Chung,
T. C. Peterson,
D. K. Wilton,
A. Frouin,
B. A. Napier,
N. Panicker,
M. Kumar,
M. S. Buckwalter,
D. H. Rowitch,
V. L. Dawson,
T. M. Dawson,
B. Stevens,
B. A. Barres
, Neurotoxic reactive astrocytes are induced by activated microglia. Nature 541, 481–487 (2017).
OpenUrl

[17] S. A. Liddelow,

[18] K. A. Guttenplan,

[19] L. E. Clarke,

[20] F. C. Bennett,

[21] C. J. Bohlen,

[22] L. Schirmer,

[23] M. L. Bennett,

[24] A. E. Münch,

[25] W.-S. Chung,

[26] T. C. Peterson,

[27] D. K. Wilton,

[28] A. Frouin,

[29] B. A. Napier,

[30] N. Panicker,

[31] M. Kumar,

[32] M. S. Buckwalter,

[33] D. H. Rowitch,

[34] V. L. Dawson,

[35] T. M. Dawson,

[36] B. Stevens,

[37] B. A. Barres

[38] A. Britschgi,
S. Duss,
S. Kim,
J. P. Couto,
H. Brinkhaus,
S. Koren,
D. De Silva,
K. D. Mertz,
D. Kaup,
Z. Varga,
H. Voshol,
A. Vissieres,
C. Leroy,
T. Roloff,
M. B. Stadler,
C. H. Scheel,
L. J. Miraglia,
A. P. Orth,
G. M. C. Bonamy,
V. A. Reddy,
M. Bentires-Alj
, The Hippo kinases LATS1 and 2 control human breast cell fate via crosstalk with ERα. Nature 541, 541–545 (2017).
OpenUrl

[39] A. Britschgi,

[40] S. Duss,

[41] S. Kim,

[42] J. P. Couto,

[43] H. Brinkhaus,

[44] S. Koren,

[45] D. De Silva,

[46] K. D. Mertz,

[47] D. Kaup,

[48] Z. Varga,

[49] H. Voshol,

[50] A. Vissieres,

[51] C. Leroy,

[52] T. Roloff,

[53] M. B. Stadler,

[54] C. H. Scheel,

[55] L. J. Miraglia,

[56] A. P. Orth,

[57] G. M. C. Bonamy,

[58] V. A. Reddy,

[59] M. Bentires-Alj

Papers of note in Nature 541 (7638)

Highlighted Articles

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