Contents
07 February 2017
Vol 10, Issue 465
Vol 10, Issue 465
Research Articles
- Prostaglandin E2–EP2–NF-κB signaling in macrophages as a potential therapeutic target for intracranial aneurysms
Inhibition of prostaglandin E2 signaling in macrophages may be a pharmacological option for treating intracranial aneurysms.
- A cytoplasmic role of Wnt/β-catenin transcriptional cofactors Bcl9, Bcl9l, and Pygopus in tooth enamel formation
Transcriptional cofactors that participate in Wnt/β-catenin signaling act in the cytoplasm to promote proper development of tooth enamel.
Editors Choice
- Calcineurin for T cell adhesion
The phosphatase calcineurin not only activates transcription factors but also promotes T cell adhesion upon T cell activation.
- Recovering rRNA processing after heat shock
NF-κB repressing factor controls localization and activation of an rRNA processing protein in heat stress response.
- Tumors direct vessels to feed growth
Blood vessels go from blocking growth factor signaling with IGFBP7 to sending the growth factor IGF1 in response to tumor-released FGF4.
- New connections: Protein trafficking for strong bones and teeth
Distinct mechanisms of dysregulated protein secretion result in weak bones or teeth.
- Papers of note in Nature 542 (7639)
This week’s articles describe how cellular metabolism contributes to the development of lymphatic vessels, a proinflammatory cytokine that acts as a neuromodulator, how mechanical force frees a growth factor from its protein cage, and the gating mechanism of a cyclic nucleotide–gated ion channel.
- Papers of note in Science Translational Medicine 9 (375)
This week’s articles describe ways to treat arthritis caused by chikungunya virus, IDH-mutant cancers, and hypertension.
- Papers of note in Science 355 (6324)
This week’s articles show how excitatory synapses are weakened during sleep and how the catalytic subunit of PKC-cs may mediate the choice between different modes of double-strand DNA break repair.
About The Cover
Online Cover This week features a Research Article showing that transcriptional cofactors that participate in Wnt/β-catenin signaling also act in the cytoplasm to promote secretion necessary for the proper development of tooth enamel. The image shows the organized structure of the tooth enamel in wild-type mice. [Image: P. Pagella and C. Cantù, University of Zurich, Zurich, Switzerland]