Prostaglandin E2–EP2–NF-κB signaling in macrophages as a potential therapeutic target for intracranial aneurysms

Tomohiro Aoki; Juhana Frȍsen; Miyuki Fukuda; Kana Bando; Go Shioi; Keiichi Tsuji; Eliisa Ollikainen; Kazuhiko Nozaki; Johanna Laakkonen; Shuh Narumiya

doi:10.1126/scisignal.aah6037

Research ArticleVASCULAR BIOLOGY

Prostaglandin E₂–EP2–NF-κB signaling in macrophages as a potential therapeutic target for intracranial aneurysms

Tomohiro Aoki¹,²,
Juhana Frȍsen³,⁴,⁵,
Miyuki Fukuda¹,
Kana Bando⁶,⁷,
Go Shioi⁷,
Keiichi Tsuji⁸,
Eliisa Ollikainen³,
Kazuhiko Nozaki⁸,
Johanna Laakkonen⁹, and
Shuh Narumiya¹,²,*

¹Center for Innovation in Immunoregulation Technology and Therapeutics, Kyoto University Graduate School of Medicine, Kyoto 606-8501, Japan.
²Core Research for Evolutional Science and Technology, Medical Innovation Center, Kyoto University Graduate School of Medicine, Kyoto 606-8507, Japan.
³Neurosurgery Research Group, Biomedicum Helsinki, Helsinki 00029 HUS, Finland.
⁴Hemorrhagic Brain Pathology Research Group, NeuroCenter, Kuopio University Hospital, Kuopio 70029 KYS, Finland.
⁵Department of Neurosurgery, NeuroCenter, Kuopio University Hospital, Kuopio 70029 KYS, Finland.
⁶Animal Resource Development Unit, RIKEN Center for Life Science Technologies, Hyogo 650-0047, Japan.
⁷Genetic Engineering Team, RIKEN Center for Life Science Technologies, Hyogo 650-0047, Japan.
⁸Department of Neurosurgery, Shiga University of Medical Science, Shiga 520-2192, Japan.
⁹Department of Molecular Medicine, A.I. Virtanen Institute, University of Eastern Finland, Kuopio 70211, Finland.

↵*Corresponding author. Email: snaru{at}mfour.med.kyoto-u.ac.jp

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Science Signaling 07 Feb 2017:
Vol. 10, Issue 465, eaah6037
DOI: 10.1126/scisignal.aah6037

Tomohiro Aoki

1Center for Innovation in Immunoregulation Technology and Therapeutics, Kyoto University Graduate School of Medicine, Kyoto 606-8501, Japan.

2Core Research for Evolutional Science and Technology, Medical Innovation Center, Kyoto University Graduate School of Medicine, Kyoto 606-8507, Japan.

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Juhana Frȍsen

3Neurosurgery Research Group, Biomedicum Helsinki, Helsinki 00029 HUS, Finland.

4Hemorrhagic Brain Pathology Research Group, NeuroCenter, Kuopio University Hospital, Kuopio 70029 KYS, Finland.

5Department of Neurosurgery, NeuroCenter, Kuopio University Hospital, Kuopio 70029 KYS, Finland.

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Miyuki Fukuda

1Center for Innovation in Immunoregulation Technology and Therapeutics, Kyoto University Graduate School of Medicine, Kyoto 606-8501, Japan.

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Kana Bando

6Animal Resource Development Unit, RIKEN Center for Life Science Technologies, Hyogo 650-0047, Japan.

7Genetic Engineering Team, RIKEN Center for Life Science Technologies, Hyogo 650-0047, Japan.

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Go Shioi

7Genetic Engineering Team, RIKEN Center for Life Science Technologies, Hyogo 650-0047, Japan.

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Keiichi Tsuji

8Department of Neurosurgery, Shiga University of Medical Science, Shiga 520-2192, Japan.

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Eliisa Ollikainen

3Neurosurgery Research Group, Biomedicum Helsinki, Helsinki 00029 HUS, Finland.

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Kazuhiko Nozaki

8Department of Neurosurgery, Shiga University of Medical Science, Shiga 520-2192, Japan.

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Johanna Laakkonen

9Department of Molecular Medicine, A.I. Virtanen Institute, University of Eastern Finland, Kuopio 70211, Finland.

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Shuh Narumiya

1Center for Innovation in Immunoregulation Technology and Therapeutics, Kyoto University Graduate School of Medicine, Kyoto 606-8501, Japan.

2Core Research for Evolutional Science and Technology, Medical Innovation Center, Kyoto University Graduate School of Medicine, Kyoto 606-8507, Japan.

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For correspondence: snaru@mfour.med.kyoto-u.ac.jp

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