Papers of note in Science Translational Medicine 9 (375)

Leslie K. Ferrarelli

doi:10.1126/scisignal.aam9077

This week’s articles describe ways to treat arthritis caused by chikungunya virus, IDH-mutant cancers, and hypertension.

INFECTIOUS DISEASE

Taming T cells to ameliorate chikungunya arthritis

Teo et al. report that fingolimod (FTY720) prevents the accumulation of CD4⁺ T cells in the joints, thus blocking chikungunya virus–induced joint pathology.

Miner et al. show that combination therapy with CTLA4-Ig and an antiviral human monoclonal antibody controls chikungunya virus arthritis in mice.

CANCER

Metabolite as cancer’s Achilles’ heel

Sulkowski et al. discover that the oncometabolite 2-hydroxyglutarate renders IDH1/2 mutant cancer cells deficient in homologous recombination and confers vulnerability to synthetic lethal targeting with PARP inhibitors.

HYPERTENSION

Targeting platelets to control high blood pressure

Kossmann et al. identify a coagulation-inflammation circuit that promotes vascular dysfunction, revealing that factor XI–targeted anticoagulants may be useful for treating hypertension.

Highlighted Articles

1. T.-H. Teo,
2. Y.-H. Chan,
3. W. W. L. Lee,
4. F.-M. Lum,
5. S. N. Amrun,
6. Z. Her,
7. R. Rajarethinam,
8. A. Merits,
9. O. Rötzschke,
10. L. Rénia,
11. L. F. P. Ng
, Fingolimod treatment abrogates chikungunya virus–induced arthralgia. Sci. Transl. Med. 9, eaal1333 (2017).
OpenUrl Abstract/FREE Full Text
1. J. J. Miner,
2. L. E. Cook,
3. J. P. Hong,
4. A. M. Smith,
5. J. M. Richner,
6. R. M. Shimak,
7. A. R. Young,
8. K. Monte,
9. S. Poddar,
10. J. E. Crowe Jr.,
11. D. J. Lenschow,
12. M. S. Diamond
, Therapy with CTLA4-Ig and an antiviral monoclonal antibody controls chikungunya virus arthritis. Sci. Transl. Med. 9, eaah3438 (2017).
OpenUrl Abstract/FREE Full Text
1. P. L. Sulkowski,
2. C. D. Corso,
3. N. D. Robinson,
4. S. E. Scanlon,
5. K. R. Purshouse,
6. H. Bai,
7. Y. Liu,
8. R. K. Sundaram,
9. D. C. Hegan,
10. N. R. Fons,
11. G. A. Breuer,
12. Y. Song,
13. K. Mishra-Gorur,
14. H. M. De Feyter,
15. R. A. de Graaf,
16. Y. V. Surovtseva,
17. M. Kachman,
18. S. Halene,
19. M. Günel,
20. P. M. Glazer,
21. R. S. Bindra
, 2-Hydroxyglutarate produced by neomorphic IDH mutations suppresses homologous recombination and induces PARP inhibitor sensitivity. Sci. Transl. Med. 9, eaal2463 (2017).
OpenUrl Abstract/FREE Full Text
1. S. Kossmann,
2. J. Lagrange,
3. S. Jäckel,
4. K. Jurk,
5. M. Ehlken,
6. T. Schönfelder,
7. Y. Weihert,
8. M. Knorr,
9. M. Brandt,
10. N. Xia,
11. H. Li,
12. A. Daiber,
13. M. Oelze,
14. C. Reinhardt,
15. K. Lackner,
16. A. Gruber,
17. B. Monia,
18. S. H. Karbach,
19. U. Walter,
20. Z. M. Ruggeri,
21. T. Renné,
22. W. Ruf,
23. T. Münzel,
24. P. Wenzel
, Platelet-localized FXI promotes a vascular coagulation-inflammatory circuit in arterial hypertension. Sci. Transl. Med. 9, eaah4923 (2017).
OpenUrl Abstract/FREE Full Text

View Abstract

[1] T.-H. Teo,
Y.-H. Chan,
W. W. L. Lee,
F.-M. Lum,
S. N. Amrun,
Z. Her,
R. Rajarethinam,
A. Merits,
O. Rötzschke,
L. Rénia,
L. F. P. Ng
, Fingolimod treatment abrogates chikungunya virus–induced arthralgia. Sci. Transl. Med. 9, eaal1333 (2017).
OpenUrl Abstract/FREE Full Text

[2] T.-H. Teo,

[3] Y.-H. Chan,

[4] W. W. L. Lee,

[5] F.-M. Lum,

[6] S. N. Amrun,

[7] Z. Her,

[8] R. Rajarethinam,

[9] A. Merits,

[10] O. Rötzschke,

[11] L. Rénia,

[12] L. F. P. Ng

[13] J. J. Miner,
L. E. Cook,
J. P. Hong,
A. M. Smith,
J. M. Richner,
R. M. Shimak,
A. R. Young,
K. Monte,
S. Poddar,
J. E. Crowe Jr.,
D. J. Lenschow,
M. S. Diamond
, Therapy with CTLA4-Ig and an antiviral monoclonal antibody controls chikungunya virus arthritis. Sci. Transl. Med. 9, eaah3438 (2017).
OpenUrl Abstract/FREE Full Text

[14] J. J. Miner,

[15] L. E. Cook,

[16] J. P. Hong,

[17] A. M. Smith,

[18] J. M. Richner,

[19] R. M. Shimak,

[20] A. R. Young,

[21] K. Monte,

[22] S. Poddar,

[23] J. E. Crowe Jr.,

[24] D. J. Lenschow,

[25] M. S. Diamond

[26] P. L. Sulkowski,
C. D. Corso,
N. D. Robinson,
S. E. Scanlon,
K. R. Purshouse,
H. Bai,
Y. Liu,
R. K. Sundaram,
D. C. Hegan,
N. R. Fons,
G. A. Breuer,
Y. Song,
K. Mishra-Gorur,
H. M. De Feyter,
R. A. de Graaf,
Y. V. Surovtseva,
M. Kachman,
S. Halene,
M. Günel,
P. M. Glazer,
R. S. Bindra
, 2-Hydroxyglutarate produced by neomorphic IDH mutations suppresses homologous recombination and induces PARP inhibitor sensitivity. Sci. Transl. Med. 9, eaal2463 (2017).
OpenUrl Abstract/FREE Full Text

[27] P. L. Sulkowski,

[28] C. D. Corso,

[29] N. D. Robinson,

[30] S. E. Scanlon,

[31] K. R. Purshouse,

[32] H. Bai,

[33] Y. Liu,

[34] R. K. Sundaram,

[35] D. C. Hegan,

[36] N. R. Fons,

[37] G. A. Breuer,

[38] Y. Song,

[39] K. Mishra-Gorur,

[40] H. M. De Feyter,

[41] R. A. de Graaf,

[42] Y. V. Surovtseva,

[43] M. Kachman,

[44] S. Halene,

[45] M. Günel,

[46] P. M. Glazer,

[47] R. S. Bindra

[48] S. Kossmann,
J. Lagrange,
S. Jäckel,
K. Jurk,
M. Ehlken,
T. Schönfelder,
Y. Weihert,
M. Knorr,
M. Brandt,
N. Xia,
H. Li,
A. Daiber,
M. Oelze,
C. Reinhardt,
K. Lackner,
A. Gruber,
B. Monia,
S. H. Karbach,
U. Walter,
Z. M. Ruggeri,
T. Renné,
W. Ruf,
T. Münzel,
P. Wenzel
, Platelet-localized FXI promotes a vascular coagulation-inflammatory circuit in arterial hypertension. Sci. Transl. Med. 9, eaah4923 (2017).
OpenUrl Abstract/FREE Full Text

[49] S. Kossmann,

[50] J. Lagrange,

[51] S. Jäckel,

[52] K. Jurk,

[53] M. Ehlken,

[54] T. Schönfelder,

[55] Y. Weihert,

[56] M. Knorr,

[57] M. Brandt,

[58] N. Xia,

[59] H. Li,

[60] A. Daiber,

[61] M. Oelze,

[62] C. Reinhardt,

[63] K. Lackner,

[64] A. Gruber,

[65] B. Monia,

[66] S. H. Karbach,

[67] U. Walter,

[68] Z. M. Ruggeri,

[69] T. Renné,

[70] W. Ruf,

[71] T. Münzel,

[72] P. Wenzel

Papers of note in Science Translational Medicine 9 (375)

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