This week’s articles describe ways to treat arthritis caused by chikungunya virus, IDH-mutant cancers, and hypertension.
INFECTIOUS DISEASE
Taming T cells to ameliorate chikungunya arthritis
Teo et al. report that fingolimod (FTY720) prevents the accumulation of CD4+ T cells in the joints, thus blocking chikungunya virus–induced joint pathology.
Miner et al. show that combination therapy with CTLA4-Ig and an antiviral human monoclonal antibody controls chikungunya virus arthritis in mice.
CANCER
Metabolite as cancer’s Achilles’ heel
Sulkowski et al. discover that the oncometabolite 2-hydroxyglutarate renders IDH1/2 mutant cancer cells deficient in homologous recombination and confers vulnerability to synthetic lethal targeting with PARP inhibitors.
HYPERTENSION
Targeting platelets to control high blood pressure
Kossmann et al. identify a coagulation-inflammation circuit that promotes vascular dysfunction, revealing that factor XI–targeted anticoagulants may be useful for treating hypertension.