Editors' ChoiceCellular and Molecular Signaling

Papers of note in Science 355 (6324)

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Science Signaling  07 Feb 2017:
Vol. 10, Issue 465, eaam9084
DOI: 10.1126/scisignal.aam9084

This week’s articles show how excitatory synapses are weakened during sleep and how the catalytic subunit of PKC-cs may mediate the choice between different modes of double-strand DNA break repair.


Synapse remodeling during sleep

de Vivo et al. report that a few hours of sleep leads to a decrease in the size of synapses in the cortex of the brain (see also Acsády and Harris).

Diering et al. found that excitatory synapses are globally weakened during sleep (see also Acsády and Harris).


Activating DNA repair

Sibanda et al. present a crystal structure that shows how components of the nonhomologous end-joining machinery modulate kinase activation in DNA repair.

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