Contents
14 February 2017
Vol 10, Issue 466
Vol 10, Issue 466
Research Articles
- The host microRNA miR-301a blocks the IRF1-mediated neuronal innate immune response to Japanese encephalitis virus infection
Targeting a microRNA that inhibits type I interferon production may be a strategy to treat Japanese encephalitis virus infection.
- Acetylation-dependent regulation of MDM2 E3 ligase activity dictates its oncogenic function
Acetylation of MDM2 promotes its oncogenic function by blocking its self-ubiquitination while enhancing its ubiquitination of the tumor suppressor p53.
Research Resource
- A high-throughput, image-based screen to identify kinases involved in brown adipocyte development
Multiple kinases are potential targets to enhance the development and function of brown fat.
Editors Choice
- Tamoxifen as an immunotherapy
Antiestrogen drugs may treat some estrogen receptor–negative tumors by limiting the proliferation and activity of suppressive immune cells.
- When silencing mRNA, position matters
The mechanism of posttranscriptional silencing by an RNA-binding protein depends on the position of the protein-binding sequence in the mRNA.
- Pseudophosphatase as E3 ubiquitin ligase inhibitor
The pseudophosphatase STYX prevents the substrate recognition subunit FBXW7 from binding the catalytic E3 ubiquitin ligase complex.
- Papers of note in Science Translational Medicine 9 (376)
This week’s articles describe a free radical scavenger for treating hypertension; an engineered bacterium as a cancer immunotherapy; commensal bacteria that protect newborn mice from pneumonia; and a form of gastrointestinal E. coli that triggers proinflammatory systemic inflammation, arthritis, and colitis.
- Papers of note in Science 355 (6325)
This week’s articles report that neural activity promotes localized miRNA-mediated translational silencing at synapses and that activation of B cells triggers an unusual form of autophagy in these cells.
- Papers of note in Nature 542 (7640)
This week’s articles show how intestinal immune cell populations are controlled and how epithelial cells recognize oncogenic neighbors.
About The Cover
Online Cover This week features a Research Article that shows that Japanese encephalitis virus (JEV) suppresses the immune response in infected neuronal cells by increasing the expression of a microRNA that prevents the production of type I interferons. Blocking this microRNA in JEV-infected mice inhibited viral replication and increased survival. The image depicts viruses affecting a neuron. [Image: Kateryna Kon/shutterstock]