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Research ArticleBiochemistry
Acetylation-dependent regulation of MDM2 E3 ligase activity dictates its oncogenic function
- View ORCID ProfileNaoe T. Nihira1,
- Kohei Ogura1,2,
- View ORCID ProfileKouhei Shimizu1,3,
- View ORCID ProfileBrian J. North1,
- Jinfang Zhang1,
- Daming Gao1,4,
- View ORCID ProfileHiroyuki Inuzuka1,3,*, and
- View ORCID ProfileWenyi Wei1,*
- 1Department of Pathology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02115, USA.
- 2Department of Infectious Diseases, National Center for Global Health and Medicine, Tokyo 162-8655, Japan.
- 3Center for Advanced Stem Cell and Regenerative Research, Tohoku University Graduate School of Dentistry, Sendai 980-8575, Japan.
- 4Institute of Biochemistry and Cell Biology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, 320 Yue-yang Road, Shanghai 200031, China.
- ↵*Corresponding author. Email: wwei2{at}bidmc.harvard.edu (W.W.); hinuzuka{at}bidmc.harvard.edu (H.I.)
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Science Signaling 14 Feb 2017:
Vol. 10, Issue 466, eaai8026
DOI: 10.1126/scisignal.aai8026
Vol. 10, Issue 466, eaai8026
DOI: 10.1126/scisignal.aai8026
Naoe T. Nihira
1Department of Pathology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02115, USA.
Kohei Ogura
1Department of Pathology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02115, USA.
2Department of Infectious Diseases, National Center for Global Health and Medicine, Tokyo 162-8655, Japan.
Kouhei Shimizu
1Department of Pathology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02115, USA.
3Center for Advanced Stem Cell and Regenerative Research, Tohoku University Graduate School of Dentistry, Sendai 980-8575, Japan.
Brian J. North
1Department of Pathology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02115, USA.
Jinfang Zhang
1Department of Pathology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02115, USA.
Daming Gao
1Department of Pathology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02115, USA.
4Institute of Biochemistry and Cell Biology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, 320 Yue-yang Road, Shanghai 200031, China.
Hiroyuki Inuzuka
1Department of Pathology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02115, USA.
3Center for Advanced Stem Cell and Regenerative Research, Tohoku University Graduate School of Dentistry, Sendai 980-8575, Japan.
Wenyi Wei
1Department of Pathology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02115, USA.
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