Research ArticleCancer
Pentraxin-3 is a PI3K signaling target that promotes stem cell–like traits in basal-like breast cancers
- View ORCID ProfileClémence Thomas1,
- Whitney Henry1,
- View ORCID ProfileBenjamin G. Cuiffo1,
- Anthony Y. Collmann1,
- Elisabetta Marangoni2,
- Vanessa Benhamo2,
- Manoj K. Bhasin3,
- View ORCID ProfileCheng Fan4,
- View ORCID ProfileLaetitia Fuhrmann2,
- Albert S. Baldwin4,
- View ORCID ProfileCharles Perou4,
- Anne Vincent-Salomon2,
- Alex Toker1, and
- View ORCID ProfileAntoine E. Karnoub1,5,6,*
- 1Department of Pathology and Cancer Center, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215, USA.
- 2Institut Curie, Paris Cedex 05, France.
- 3Department of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215, USA.
- 4Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA.
- 5Harvard Stem Cell Institute, Cambridge, MA 02138, USA.
- 6Broad Institute of Massachusetts Institute of Technology and Harvard, Cambridge, MA 02142, USA.
- ↵*Corresponding author. Email: akarnoub{at}bidmc.harvard.edu
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Science Signaling 21 Feb 2017:
Vol. 10, Issue 467, eaah4674
DOI: 10.1126/scisignal.aah4674
Vol. 10, Issue 467, eaah4674
DOI: 10.1126/scisignal.aah4674
Clémence Thomas
1Department of Pathology and Cancer Center, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215, USA.
Whitney Henry
1Department of Pathology and Cancer Center, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215, USA.
Benjamin G. Cuiffo
1Department of Pathology and Cancer Center, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215, USA.
Anthony Y. Collmann
1Department of Pathology and Cancer Center, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215, USA.
Elisabetta Marangoni
2Institut Curie, Paris Cedex 05, France.
Vanessa Benhamo
2Institut Curie, Paris Cedex 05, France.
Manoj K. Bhasin
3Department of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215, USA.
Cheng Fan
4Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA.
Laetitia Fuhrmann
2Institut Curie, Paris Cedex 05, France.
Albert S. Baldwin
4Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA.
Charles Perou
4Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA.
Anne Vincent-Salomon
2Institut Curie, Paris Cedex 05, France.
Alex Toker
1Department of Pathology and Cancer Center, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215, USA.
Antoine E. Karnoub
1Department of Pathology and Cancer Center, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215, USA.
5Harvard Stem Cell Institute, Cambridge, MA 02138, USA.
6Broad Institute of Massachusetts Institute of Technology and Harvard, Cambridge, MA 02142, USA.
