Papers of note in Nature 542 (7641)

Annalisa M. VanHook

doi:10.1126/scisignal.aam9984

This week’s articles highlight a tRNA synthetase in mTORC1 signaling in fat cell metabolism and aging, the vulnerability of cancer cells to drugs that target proteostasis, and a mechanism by which stressed neurons expel protein aggregates and dysfunctional organelles.

METABOLISM

Promoting adiposity and aging

Arif et al. report that mTORC1 signals through a tRNA synthetase that binds to a lipid transporter to promote lipid uptake by adipocytes and aging in mice (see also Selman and Withers).

CANCER

Targeting proteostasis in pancreatic cancer

Genovese et al. found that the metabolic reprogramming that enables pancreatic cancer cells to escape dependence on oncogenic Kras signaling also sensitizes the cells to drugs that interfere with proteostasis.

NEUROSCIENCE

Neuronal release of aggregated proteins and dysfunctional mitochondria

Melentijevic et al. demonstrate that neurotoxic stress causes C. elegans neurons to expel protein aggregates and dysfunctional mitochondria, a phenomenon that could contribute to the cell-to-cell transmission of neurodegenerative pathology.

Highlighted Articles

1. A. Arif,
2. F. Terenzi,
3. A. A. Potdar,
4. J. Jia,
5. J. Sacks,
6. A. China,
7. D. Halawani,
8. K. Vasu,
9. X. Li,
10. J. M. Brown,
11. J. Chen,
12. S. C. Kozma,
13. G. Thomas,
14. P. L. Fox
, EPRS is a critical mTORC1-S6K1 effector that influences adiposity in mice. Nature 542, 357–361 (2017).
OpenUrl
1. C. Selman,
2. D. J. Withers
, Physiology: An atypical switch for metabolism and ageing. Nature 542, 299–300 (2017).
OpenUrl
1. G. Genovese,
2. A. Carugo,
3. J. Tepper,
4. F. S. Robinson,
5. L. Li,
6. M. Svelto,
7. L. Nezi,
8. D. Corti,
9. R. Minelli,
10. P. Pettazzoni,
11. T. Gutschner,
12. C.-C. Wu,
13. S. Seth,
14. K. C. Akdemir,
15. E. Leo,
16. S. Amin,
17. M. D. Molin,
18. H. Ying,
19. L. N. Kwong,
20. S. Colla,
21. K. Takahashi,
22. P. Ghosh,
23. V. Giuliani,
24. F. Muller,
25. P. Dey,
26. S. Jiang,
27. J. Garvey,
28. C.-G. Liu,
29. J. Zhang,
30. T. P. Heffernan,
31. C. Toniatti,
32. J. B. Fleming,
33. M. G. Goggins,
34. L. D. Wood,
35. A. Sgambato,
36. A. Agaimy,
37. A. Maitra,
38. C. W. M. Roberts,
39. H. Wang,
40. A. Viale,
41. R. A. DePinho,
42. G. F. Draetta,
43. L. Chin
, Synthetic vulnerabilities of mesenchymal subpopulations in pancreatic cancer. Nature 542, 362–366 (2017).
OpenUrl
1. I. Melentijevic,
2. M. L. Toth,
3. M. L. Arnold,
4. R. J. Guasp,
5. G. Harinath,
6. K. C. Nguyen,
7. D. Taub,
8. J. A. Parker,
9. C. Neri,
10. C. V. Gabel,
11. D. H. Hall,
12. M. Driscoll
, C. elegans neurons jettison protein aggregates and mitochondria under neurotoxic stress. Nature 542, 367–371 (2017).
OpenUrl

View Abstract

[1] A. Arif,
F. Terenzi,
A. A. Potdar,
J. Jia,
J. Sacks,
A. China,
D. Halawani,
K. Vasu,
X. Li,
J. M. Brown,
J. Chen,
S. C. Kozma,
G. Thomas,
P. L. Fox
, EPRS is a critical mTORC1-S6K1 effector that influences adiposity in mice. Nature 542, 357–361 (2017).
OpenUrl

[2] A. Arif,

[3] F. Terenzi,

[4] A. A. Potdar,

[5] J. Jia,

[6] J. Sacks,

[7] A. China,

[8] D. Halawani,

[9] K. Vasu,

[10] X. Li,

[11] J. M. Brown,

[12] J. Chen,

[13] S. C. Kozma,

[14] G. Thomas,

[15] P. L. Fox

[16] C. Selman,
D. J. Withers
, Physiology: An atypical switch for metabolism and ageing. Nature 542, 299–300 (2017).
OpenUrl

[17] C. Selman,

[18] D. J. Withers

[19] G. Genovese,
A. Carugo,
J. Tepper,
F. S. Robinson,
L. Li,
M. Svelto,
L. Nezi,
D. Corti,
R. Minelli,
P. Pettazzoni,
T. Gutschner,
C.-C. Wu,
S. Seth,
K. C. Akdemir,
E. Leo,
S. Amin,
M. D. Molin,
H. Ying,
L. N. Kwong,
S. Colla,
K. Takahashi,
P. Ghosh,
V. Giuliani,
F. Muller,
P. Dey,
S. Jiang,
J. Garvey,
C.-G. Liu,
J. Zhang,
T. P. Heffernan,
C. Toniatti,
J. B. Fleming,
M. G. Goggins,
L. D. Wood,
A. Sgambato,
A. Agaimy,
A. Maitra,
C. W. M. Roberts,
H. Wang,
A. Viale,
R. A. DePinho,
G. F. Draetta,
L. Chin
, Synthetic vulnerabilities of mesenchymal subpopulations in pancreatic cancer. Nature 542, 362–366 (2017).
OpenUrl

[20] G. Genovese,

[21] A. Carugo,

[22] J. Tepper,

[23] F. S. Robinson,

[24] L. Li,

[25] M. Svelto,

[26] L. Nezi,

[27] D. Corti,

[28] R. Minelli,

[29] P. Pettazzoni,

[30] T. Gutschner,

[31] C.-C. Wu,

[32] S. Seth,

[33] K. C. Akdemir,

[34] E. Leo,

[35] S. Amin,

[36] M. D. Molin,

[37] H. Ying,

[38] L. N. Kwong,

[39] S. Colla,

[40] K. Takahashi,

[41] P. Ghosh,

[42] V. Giuliani,

[43] F. Muller,

[44] P. Dey,

[45] S. Jiang,

[46] J. Garvey,

[47] C.-G. Liu,

[48] J. Zhang,

[49] T. P. Heffernan,

[50] C. Toniatti,

[51] J. B. Fleming,

[52] M. G. Goggins,

[53] L. D. Wood,

[54] A. Sgambato,

[55] A. Agaimy,

[56] A. Maitra,

[57] C. W. M. Roberts,

[58] H. Wang,

[59] A. Viale,

[60] R. A. DePinho,

[61] G. F. Draetta,

[62] L. Chin

[63] I. Melentijevic,
M. L. Toth,
M. L. Arnold,
R. J. Guasp,
G. Harinath,
K. C. Nguyen,
D. Taub,
J. A. Parker,
C. Neri,
C. V. Gabel,
D. H. Hall,
M. Driscoll
, C. elegans neurons jettison protein aggregates and mitochondria under neurotoxic stress. Nature 542, 367–371 (2017).
OpenUrl

[64] I. Melentijevic,

[65] M. L. Toth,

[66] M. L. Arnold,

[67] R. J. Guasp,

[68] G. Harinath,

[69] K. C. Nguyen,

[70] D. Taub,

[71] J. A. Parker,

[72] C. Neri,

[73] C. V. Gabel,

[74] D. H. Hall,

[75] M. Driscoll

Papers of note in Nature 542 (7641)

Highlighted Articles

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