Papers of note in Nature 542 (7642)

Annalisa M. VanHook

doi:10.1126/scisignal.aan0507

This week’s articles demonstrate that fat cells release miRNAs that act on distant tissues, identify a mechanism whereby transcription factors protect B cells from malignant transformation, and show that some anticancer drugs may have the unintended consequence of increasing genomic instability in B cells.

PHYSIOLOGY

miRNAs as adipokines

Thomou et al. found that adipocytes release exosomes containing microRNAs that regulate gene expression in distant tissues.

CANCER

Tumor-suppresive B cell transcription factors

Chan et al. report that two transcription factors protect B cells from malignant transformation by reducing glucose transport.

Unintended consequences of blocking PI3Kδ

Compagno et al. demonstrate that drugs that block PI3Kδ promote genomic instability in B cells (see also Fruman and O’Brien).

Highlighted Articles

1. T. Thomou,
2. M. A. Mori,
3. J. M. Dreyfuss,
4. M. Konishi,
5. M. Sakaguchi,
6. C. Wolfrum,
7. T. N. Rao,
8. J. N. Winnay,
9. R. Garcia-Martin,
10. S. K. Grinspoon,
11. P. Gorden,
12. C. R. Kahn
, Adipose-derived circulating miRNAs regulate gene expression in other tissues. Nature 542, 450–455 (2017).
OpenUrl
1. L. N. Chan,
2. Z. Chen,
3. D. Braas,
4. J.-W. Lee,
5. G. Xiao,
6. H. Geng,
7. K. N. Cosgun,
8. C. Hurtz,
9. S. Shojaee,
10. V. Cazzaniga,
11. H. Schjerven,
12. T. Ernst,
13. A. Hochhaus,
14. S. M. Kornblau,
15. M. Konopleva,
16. M. A. Pufall,
17. G. Cazzaniga,
18. G. J. Liu,
19. T. A. Milne,
20. H. P. Koeffler,
21. T. S. Ross,
22. I. Sánchez-García,
23. A. Borkhardt,
24. K. R. Yamamoto,
25. R. A. Dickins,
26. T. G. Graeber,
27. M. Müschen
, Metabolic gatekeeper function of B-lymphoid transcription factors. Nature 542, 479–483 (2017).
OpenUrl
1. M. Compagno,
2. Q. Wang,
3. C. Pighi,
4. T.-C. Cheong,
5. F.-L. Meng,
6. T. Poggio,
7. L.-S. Yeap,
8. E. Karaca,
9. R. B. Blasco,
10. F. Langellotto,
11. C. Ambrogio,
12. C. Voena,
13. A. Wiestner,
14. S. N. Kasar,
15. J. R. Brown,
16. J. Sun,
17. C. J. Wu,
18. M. Gostissa,
19. F. W. Alt,
20. R. Chiarle
, Phosphatidylinositol 3-kinase δ blockade increases genomic instability in B cells. Nature 542, 489–493 (2017).
OpenUrl
1. D. A. Fruman,
2. S. O’Brien
, Cancer: A targeted treatment with off-target risks. Nature 542, 424–425 (2017).
OpenUrl CrossRef

[1] T. Thomou,
M. A. Mori,
J. M. Dreyfuss,
M. Konishi,
M. Sakaguchi,
C. Wolfrum,
T. N. Rao,
J. N. Winnay,
R. Garcia-Martin,
S. K. Grinspoon,
P. Gorden,
C. R. Kahn
, Adipose-derived circulating miRNAs regulate gene expression in other tissues. Nature 542, 450–455 (2017).
OpenUrl

[2] T. Thomou,

[3] M. A. Mori,

[4] J. M. Dreyfuss,

[5] M. Konishi,

[6] M. Sakaguchi,

[7] C. Wolfrum,

[8] T. N. Rao,

[9] J. N. Winnay,

[10] R. Garcia-Martin,

[11] S. K. Grinspoon,

[12] P. Gorden,

[13] C. R. Kahn

[14] L. N. Chan,
Z. Chen,
D. Braas,
J.-W. Lee,
G. Xiao,
H. Geng,
K. N. Cosgun,
C. Hurtz,
S. Shojaee,
V. Cazzaniga,
H. Schjerven,
T. Ernst,
A. Hochhaus,
S. M. Kornblau,
M. Konopleva,
M. A. Pufall,
G. Cazzaniga,
G. J. Liu,
T. A. Milne,
H. P. Koeffler,
T. S. Ross,
I. Sánchez-García,
A. Borkhardt,
K. R. Yamamoto,
R. A. Dickins,
T. G. Graeber,
M. Müschen
, Metabolic gatekeeper function of B-lymphoid transcription factors. Nature 542, 479–483 (2017).
OpenUrl

[15] L. N. Chan,

[16] Z. Chen,

[17] D. Braas,

[18] J.-W. Lee,

[19] G. Xiao,

[20] H. Geng,

[21] K. N. Cosgun,

[22] C. Hurtz,

[23] S. Shojaee,

[24] V. Cazzaniga,

[25] H. Schjerven,

[26] T. Ernst,

[27] A. Hochhaus,

[28] S. M. Kornblau,

[29] M. Konopleva,

[30] M. A. Pufall,

[31] G. Cazzaniga,

[32] G. J. Liu,

[33] T. A. Milne,

[34] H. P. Koeffler,

[35] T. S. Ross,

[36] I. Sánchez-García,

[37] A. Borkhardt,

[38] K. R. Yamamoto,

[39] R. A. Dickins,

[40] T. G. Graeber,

[41] M. Müschen

[42] M. Compagno,
Q. Wang,
C. Pighi,
T.-C. Cheong,
F.-L. Meng,
T. Poggio,
L.-S. Yeap,
E. Karaca,
R. B. Blasco,
F. Langellotto,
C. Ambrogio,
C. Voena,
A. Wiestner,
S. N. Kasar,
J. R. Brown,
J. Sun,
C. J. Wu,
M. Gostissa,
F. W. Alt,
R. Chiarle
, Phosphatidylinositol 3-kinase δ blockade increases genomic instability in B cells. Nature 542, 489–493 (2017).
OpenUrl

[43] M. Compagno,

[44] Q. Wang,

[45] C. Pighi,

[46] T.-C. Cheong,

[47] F.-L. Meng,

[48] T. Poggio,

[49] L.-S. Yeap,

[50] E. Karaca,

[51] R. B. Blasco,

[52] F. Langellotto,

[53] C. Ambrogio,

[54] C. Voena,

[55] A. Wiestner,

[56] S. N. Kasar,

[57] J. R. Brown,

[58] J. Sun,

[59] C. J. Wu,

[60] M. Gostissa,

[61] F. W. Alt,

[62] R. Chiarle

[63] D. A. Fruman,
S. O’Brien
, Cancer: A targeted treatment with off-target risks. Nature 542, 424–425 (2017).
OpenUrl CrossRef

[64] D. A. Fruman,

[65] S. O’Brien

Papers of note in Nature 542 (7642)

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