This week’s articles demonstrate that fat cells release miRNAs that act on distant tissues, identify a mechanism whereby transcription factors protect B cells from malignant transformation, and show that some anticancer drugs may have the unintended consequence of increasing genomic instability in B cells.
PHYSIOLOGY
miRNAs as adipokines
Thomou et al. found that adipocytes release exosomes containing microRNAs that regulate gene expression in distant tissues.
CANCER
Tumor-suppresive B cell transcription factors
Chan et al. report that two transcription factors protect B cells from malignant transformation by reducing glucose transport.
Unintended consequences of blocking PI3Kδ
Compagno et al. demonstrate that drugs that block PI3Kδ promote genomic instability in B cells (see also Fruman and O’Brien).