Papers of note in Science Translational Medicine 9 (379)

Leslie K. Ferrarelli

doi:10.1126/scisignal.aan0901

This week’s articles identify a potential marker by which to stratify patients for immunotherapy and the ability of gut microbes to influence host behavior and intestinal function.

CANCER

Checking on checkpoint inhibitors

Roh et al. discover that T cell receptor profiles may predict therapeutic response or resistance of melanoma patients to PD-1 or CTLA-4 checkpoint-blocking drugs, suggesting that these profiles may help identify patients most likely to respond well to these immunotherapies and avoid the unnecessary risk and expense in patients who are unlikely to respond.

HOST-MICROBE SIGNALING

Connecting the gut-brain axis

De Palma et al. report that fecal transplants from patients with irritable bowel syndrome and anxiety to mice altered intestinal function and behavior that were associated with differences in serum metabolomic profiles, suggesting that gut microbes release both short-range factors that signal to the gut epithelia and long-range factors that signal to the brain through the circulation.

Highlighted Articles

1. W. Roh,
2. P.-L. Chen,
3. A. Reuben,
4. C. N. Spencer,
5. P. A. Prieto,
6. J. P. Miller,
7. V. Gopalakrishnan,
8. F. Wang,
9. Z. A. Cooper,
10. S. M. Reddy,
11. C. Gumbs,
12. L. Little,
13. Q. Chang,
14. W.-S. Chen,
15. K. Wani,
16. M. P. De Macedo,
17. E. Chen,
18. J. L. Austin-Breneman,
19. H. Jiang,
20. J. Roszik,
21. M. T. Tetzlaff,
22. M. A. Davies,
23. J. E. Gershenwald,
24. H. Tawbi,
25. A. J. Lazar,
26. P. Hwu,
27. W.-J. Hwu,
28. A. Diab,
29. I. C. Glitza,
30. S. P. Patel,
31. S. E. Woodman,
32. R. N. Amaria,
33. V. G. Prieto,
34. J. Hu,
35. P. Sharma,
36. J. P. Allison,
37. L. Chin,
38. J. Zhang,
39. J. A. Wargo,
40. P. A. Futreal
, Integrated molecular analysis of tumor biopsies on sequential CTLA-4 and PD-1 blockade reveals markers of response and resistance. Sci. Transl. Med. 9, eaah3560 (2017).
OpenUrl Abstract/FREE Full Text
1. G. De Palma,
2. M. D. J. Lynch,
3. J. Lu,
4. V. T. Dang,
5. Y. Deng,
6. J. Jury,
7. G. Umeh,
8. P. M. Miranda,
9. M. Pigrau Pastor,
10. S. Sidani,
11. M. I. Pinto-Sanchez,
12. V. Philip,
13. P. G. McLean,
14. M.-G. Hagelsieb,
15. M. G. Surette,
16. G. E. Bergonzelli,
17. E. F. Verdu,
18. P. Britz-McKibbin,
19. J. D. Neufeld,
20. S. M. Collins,
21. P. Bercik
, Transplantation of fecal microbiota from patients with irritable bowel syndrome alters gut function and behavior in recipient mice. Sci. Transl. Med. 9, eaaf6397 (2017).
OpenUrl Abstract/FREE Full Text

This week’s articles identify a potential marker by which to stratify patients for immunotherapy and the ability of gut microbes to influence host behavior and intestinal function.

[1] W. Roh,
P.-L. Chen,
A. Reuben,
C. N. Spencer,
P. A. Prieto,
J. P. Miller,
V. Gopalakrishnan,
F. Wang,
Z. A. Cooper,
S. M. Reddy,
C. Gumbs,
L. Little,
Q. Chang,
W.-S. Chen,
K. Wani,
M. P. De Macedo,
E. Chen,
J. L. Austin-Breneman,
H. Jiang,
J. Roszik,
M. T. Tetzlaff,
M. A. Davies,
J. E. Gershenwald,
H. Tawbi,
A. J. Lazar,
P. Hwu,
W.-J. Hwu,
A. Diab,
I. C. Glitza,
S. P. Patel,
S. E. Woodman,
R. N. Amaria,
V. G. Prieto,
J. Hu,
P. Sharma,
J. P. Allison,
L. Chin,
J. Zhang,
J. A. Wargo,
P. A. Futreal
, Integrated molecular analysis of tumor biopsies on sequential CTLA-4 and PD-1 blockade reveals markers of response and resistance. Sci. Transl. Med. 9, eaah3560 (2017).
OpenUrl Abstract/FREE Full Text

[2] W. Roh,

[3] P.-L. Chen,

[4] A. Reuben,

[5] C. N. Spencer,

[6] P. A. Prieto,

[7] J. P. Miller,

[8] V. Gopalakrishnan,

[9] F. Wang,

[10] Z. A. Cooper,

[11] S. M. Reddy,

[12] C. Gumbs,

[13] L. Little,

[14] Q. Chang,

[15] W.-S. Chen,

[16] K. Wani,

[17] M. P. De Macedo,

[18] E. Chen,

[19] J. L. Austin-Breneman,

[20] H. Jiang,

[21] J. Roszik,

[22] M. T. Tetzlaff,

[23] M. A. Davies,

[24] J. E. Gershenwald,

[25] H. Tawbi,

[26] A. J. Lazar,

[27] P. Hwu,

[28] W.-J. Hwu,

[29] A. Diab,

[30] I. C. Glitza,

[31] S. P. Patel,

[32] S. E. Woodman,

[33] R. N. Amaria,

[34] V. G. Prieto,

[35] J. Hu,

[36] P. Sharma,

[37] J. P. Allison,

[38] L. Chin,

[39] J. Zhang,

[40] J. A. Wargo,

[41] P. A. Futreal

[42] G. De Palma,
M. D. J. Lynch,
J. Lu,
V. T. Dang,
Y. Deng,
J. Jury,
G. Umeh,
P. M. Miranda,
M. Pigrau Pastor,
S. Sidani,
M. I. Pinto-Sanchez,
V. Philip,
P. G. McLean,
M.-G. Hagelsieb,
M. G. Surette,
G. E. Bergonzelli,
E. F. Verdu,
P. Britz-McKibbin,
J. D. Neufeld,
S. M. Collins,
P. Bercik
, Transplantation of fecal microbiota from patients with irritable bowel syndrome alters gut function and behavior in recipient mice. Sci. Transl. Med. 9, eaaf6397 (2017).
OpenUrl Abstract/FREE Full Text

[43] G. De Palma,

[44] M. D. J. Lynch,

[45] J. Lu,

[46] V. T. Dang,

[47] Y. Deng,

[48] J. Jury,

[49] G. Umeh,

[50] P. M. Miranda,

[51] M. Pigrau Pastor,

[52] S. Sidani,

[53] M. I. Pinto-Sanchez,

[54] V. Philip,

[55] P. G. McLean,

[56] M.-G. Hagelsieb,

[57] M. G. Surette,

[58] G. E. Bergonzelli,

[59] E. F. Verdu,

[60] P. Britz-McKibbin,

[61] J. D. Neufeld,

[62] S. M. Collins,

[63] P. Bercik

Papers of note in Science Translational Medicine 9 (379)

Highlighted Articles

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