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This week’s articles highlight the role of autophagy in maintaining stem cells and a new player in the repair of double-strand DNA breaks.

STEM CELLS

How autophagy promotes stemness

Ho et al. found that autophagy maintains the stemness and quiescence of hematopoietic stem cells by ridding the cells of active mitochondria.

DNA REPAIR

A new partner for the DNA repair protein 53BP1

Drané et al. identified a protein that prevents the double-strand break repair protein 53BP1 from binding to DNA until damage is detected.

Highlighted Articles

1. T. T. Ho,
2. M. R. Warr,
3. E. R. Adelman,
4. O. M. Lansinger,
5. J. Flach,
6. E. V. Verovskaya,
7. M. E. Figueroa,
8. E. Passegué
, Autophagy maintains the metabolism and function of young and old stem cells. Nature 543, 205–210 (2017).
OpenUrl
1. P. Drané,
2. M.-E. Brault,
3. G. Cui,
4. K. Meghani,
5. S. Chaubey,
6. A. Detappe,
7. N. Parnandi,
8. Y. He,
9. X.-F. Zheng,
10. M. V. Botuyan,
11. A. Kalousi,
12. W. T. Yewdell,
13. C. Münch,
14. J. W. Harper,
15. J. Chaudhuri,
16. E. Soutoglou,
17. G. Mer,
18. D. Chowdhury
, TIRR regulates 53BP1 by masking its histone methyl-lysine binding function. Nature 543, 211–216 (2017).
OpenUrl

Science Signaling: 10 (470)

Science Signaling

Vol 10, Issue 470
14 March 2017

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Papers of note in Nature 543 (7644)

By Annalisa M. VanHook

Science Signaling14 Mar 2017

This week’s articles highlight the role of autophagy in maintaining stem cells and a new player in the repair of double-strand DNA breaks.

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Papers of note in Nature 543 (7644)

By Annalisa M. VanHook

Science Signaling14 Mar 2017

This week’s articles highlight the role of autophagy in maintaining stem cells and a new player in the repair of double-strand DNA breaks.

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