This week’s articles describe an antibody that inhibits two pathways that drive lung cancer and a new way to lessen colitis in Crohn’s disease.
CANCER
Two targets for a bigger punch
Hu et al. generated a customized, dual-targeted antibody that can simultaneously inhibit both the EGFR and Notch pathways to overcome drug resistance in non–small cell lung cancer.
MICROBIOTA
Fungi and inflammatory bowel disease
Chiaro et al. discovered that blocking purine metabolism in gut Saccharomyces cerevisiae may reverse colitis in patients with Crohn’s disease.