Papers of note in Science Translational Medicine 9 (380)

Leslie K. Ferrarelli

doi:10.1126/scisignal.aan1407

This week’s articles describe an antibody that inhibits two pathways that drive lung cancer and a new way to lessen colitis in Crohn’s disease.

CANCER

Two targets for a bigger punch

Hu et al. generated a customized, dual-targeted antibody that can simultaneously inhibit both the EGFR and Notch pathways to overcome drug resistance in non–small cell lung cancer.

MICROBIOTA

Fungi and inflammatory bowel disease

Chiaro et al. discovered that blocking purine metabolism in gut Saccharomyces cerevisiae may reverse colitis in patients with Crohn’s disease.

Highlighted Articles

1. S. Hu,
2. W. Fu,
3. T. Li,
4. Q. Yuan,
5. F. Wang,
6. G. Lv,
7. Y. Lv,
8. X. Fan,
9. Y. Shen,
10. F. Lin,
11. Y. Tang,
12. X. Ye,
13. Y. Yang,
14. C. Lei
, Antagonism of EGFR and Notch limits resistance to EGFR inhibitors and radiation by decreasing tumor-initiating cell frequency. Sci. Transl. Med. 9, eaag0339 (2017).
OpenUrl Abstract/FREE Full Text
1. T. R. Chiaro,
2. R. Soto,
3. W. Z. Stephens,
4. J. L. Kubinak,
5. C. Petersen,
6. L. Gogokhia,
7. R. Bell,
8. J. C. Delgado,
9. J. Cox,
10. W. Voth,
11. J. Brown,
12. D. J. Stillman,
13. R. M. O’Connell,
14. A. E. Tebo,
15. J. L. Round
, A member of the gut mycobiota modulates host purine metabolism exacerbating colitis in mice. Sci. Transl. Med. 9, eaaf9044 (2017).
OpenUrl Abstract/FREE Full Text

View Abstract

[1] S. Hu,
W. Fu,
T. Li,
Q. Yuan,
F. Wang,
G. Lv,
Y. Lv,
X. Fan,
Y. Shen,
F. Lin,
Y. Tang,
X. Ye,
Y. Yang,
C. Lei
, Antagonism of EGFR and Notch limits resistance to EGFR inhibitors and radiation by decreasing tumor-initiating cell frequency. Sci. Transl. Med. 9, eaag0339 (2017).
OpenUrl Abstract/FREE Full Text

[2] S. Hu,

[3] W. Fu,

[4] T. Li,

[5] Q. Yuan,

[6] F. Wang,

[7] G. Lv,

[8] Y. Lv,

[9] X. Fan,

[10] Y. Shen,

[11] F. Lin,

[12] Y. Tang,

[13] X. Ye,

[14] Y. Yang,

[15] C. Lei

[16] T. R. Chiaro,
R. Soto,
W. Z. Stephens,
J. L. Kubinak,
C. Petersen,
L. Gogokhia,
R. Bell,
J. C. Delgado,
J. Cox,
W. Voth,
J. Brown,
D. J. Stillman,
R. M. O’Connell,
A. E. Tebo,
J. L. Round
, A member of the gut mycobiota modulates host purine metabolism exacerbating colitis in mice. Sci. Transl. Med. 9, eaaf9044 (2017).
OpenUrl Abstract/FREE Full Text

[17] T. R. Chiaro,

[18] R. Soto,

[19] W. Z. Stephens,

[20] J. L. Kubinak,

[21] C. Petersen,

[22] L. Gogokhia,

[23] R. Bell,

[24] J. C. Delgado,

[25] J. Cox,

[26] W. Voth,

[27] J. Brown,

[28] D. J. Stillman,

[29] R. M. O’Connell,

[30] A. E. Tebo,

[31] J. L. Round

Papers of note in Science Translational Medicine 9 (380)

Highlighted Articles

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