Contents
21 March 2017
Vol 10, Issue 471
Vol 10, Issue 471
Research Articles
- Structural basis for chemokine recognition by a G protein–coupled receptor and implications for receptor activation
Structural analysis of the interactions between a receptor and monomeric or dimeric forms of its ligand may aid in drug design.
- Phosphorylation of the exocyst protein Exo84 by TBK1 promotes insulin-stimulated GLUT4 trafficking
An inflammation-associated kinase also stimulates glucose uptake through plasma membrane translocation of GLUT4 in response to insulin.
Research Resource
- Neuropathic pain promotes adaptive changes in gene expression in brain networks involved in stress and depression
Common changes in signaling pathway–associated gene expression may explain why chronic pain or stress can lead to depression.
Editors' Choice
- Autophagy and vitamin D
Vitamin D receptor represses basal autophagy in breast tissue, which is derepressed by vitamin D, slowing cancer progression.
- New connections: Getting the good without the bad, opiate edition
Researchers identify strategies to limit the adverse effects and liabilities of opioid receptor–targeting drugs.
- Papers of note in Science 355 (6330)
This week’s articles include several reviews on targeting signaling pathways to treat cancer, as well as research articles that highlight proteins that drive circadian clocks; how bacteriophages affect the virulence of pathogenic bacteria; a mobile transcription factor in plants; a secreted nucleoside that affects metabolism; and the effects of protein aggregation in aging yeast cells.
- Paper of note in Science Translational Medicine 9 (381)
This week’s article describes a therapy that may enable macrophages to recognize and kill tumor cells in pediatric patients with brain cancer.
- Papers of note in Nature 543 (7645)
This week’s articles highlight a function for disordered protein domains, how fish sense electric fields, the subcellular localization of nutrient sensing, metabolism in intestinal stem cells, the bone as an endocrine organ, signaling pathways that are dysregulated in cervical cancer, and a drug that stimulates the recruitment of antitumor macrophages.
About The Cover
Online Cover This week features a Research Resource that identifies transcriptional links between chronic pain, stress and depression. The image shows a person suffering from stress and depression. [Image: OcusFocus/iStockphoto]