Stress-induced dynamic regulation of mitochondrial STAT3 and its association with cyclophilin D reduce mitochondrial ROS production

Jeremy A. Meier; Moonjung Hyun; Marc Cantwell; Ali Raza; Claudia Mertens; Vidisha Raje; Jennifer Sisler; Erin Tracy; Sylvia Torres-Odio; Suzana Gispert; Peter E. Shaw; Heinz Baumann; Dipankar Bandyopadhyay; Kazuaki Takabe; Andrew C. Larner

doi:10.1126/scisignal.aag2588

Research ArticleCell Biology

Stress-induced dynamic regulation of mitochondrial STAT3 and its association with cyclophilin D reduce mitochondrial ROS production

View ORCID ProfileJeremy A. Meier¹,²,*,
View ORCID ProfileMoonjung Hyun²,*,
Marc Cantwell¹,²,
View ORCID ProfileAli Raza²,³,
Claudia Mertens⁴,
View ORCID ProfileVidisha Raje²,
Jennifer Sisler²,
View ORCID ProfileErin Tracy⁵,
Sylvia Torres-Odio⁶,
Suzana Gispert⁶,
Peter E. Shaw⁷,
Heinz Baumann⁵,
Dipankar Bandyopadhyay⁸,
View ORCID ProfileKazuaki Takabe²,³,⁹,¹⁰, and
View ORCID ProfileAndrew C. Larner²,†

¹Center for Clinical and Translational Research, Virginia Commonwealth University, Richmond, VA 23298, USA.
²Department of Biochemistry and Molecular Biology and Massey Cancer Center, Virginia Commonwealth University, Richmond, VA 23298, USA.
³Division of Surgical Oncology, Virginia Commonwealth University School of Medicine, Richmond, VA 23298, USA.
⁴Laboratory of Molecular Cell Biology, Rockefeller University, New York, NY 10065, USA.
⁵Department of Molecular and Cellular Biology, Roswell Park Cancer Institute, Buffalo, NY 14263, USA.
⁶Experimental Neurology, Goethe University Medical School, Frankfurt am Main, Germany.
⁷School of Life Sciences, University of Nottingham, Nottingham, U.K.
⁸Department of Biostatistics, Virginia Commonwealth University School of Medicine, Richmond, VA 23298, USA.
⁹Division of Breast Surgery, Department of Surgical Oncology, Roswell Park Cancer Institute, Buffalo, NY 14263, USA.
¹⁰Department of Surgery, Jacobs School of Medicine and Biomedical Sciences, University at Buffalo, State University of New York, Buffalo, NY 14203, USA.

↵†Corresponding author. Email: andrew.larner{at}vcuhealth.org

↵* These authors contributed equally to this work.

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Science Signaling 28 Mar 2017:
Vol. 10, Issue 472, eaag2588
DOI: 10.1126/scisignal.aag2588

Jeremy A. Meier

1Center for Clinical and Translational Research, Virginia Commonwealth University, Richmond, VA 23298, USA.

2Department of Biochemistry and Molecular Biology and Massey Cancer Center, Virginia Commonwealth University, Richmond, VA 23298, USA.

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Moonjung Hyun

2Department of Biochemistry and Molecular Biology and Massey Cancer Center, Virginia Commonwealth University, Richmond, VA 23298, USA.

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Marc Cantwell

1Center for Clinical and Translational Research, Virginia Commonwealth University, Richmond, VA 23298, USA.

2Department of Biochemistry and Molecular Biology and Massey Cancer Center, Virginia Commonwealth University, Richmond, VA 23298, USA.

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Ali Raza

2Department of Biochemistry and Molecular Biology and Massey Cancer Center, Virginia Commonwealth University, Richmond, VA 23298, USA.

3Division of Surgical Oncology, Virginia Commonwealth University School of Medicine, Richmond, VA 23298, USA.

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Claudia Mertens

4Laboratory of Molecular Cell Biology, Rockefeller University, New York, NY 10065, USA.

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Vidisha Raje

2Department of Biochemistry and Molecular Biology and Massey Cancer Center, Virginia Commonwealth University, Richmond, VA 23298, USA.

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Jennifer Sisler

2Department of Biochemistry and Molecular Biology and Massey Cancer Center, Virginia Commonwealth University, Richmond, VA 23298, USA.

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Erin Tracy

5Department of Molecular and Cellular Biology, Roswell Park Cancer Institute, Buffalo, NY 14263, USA.

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Sylvia Torres-Odio

6Experimental Neurology, Goethe University Medical School, Frankfurt am Main, Germany.

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Suzana Gispert

6Experimental Neurology, Goethe University Medical School, Frankfurt am Main, Germany.

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Peter E. Shaw

7School of Life Sciences, University of Nottingham, Nottingham, U.K.

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Heinz Baumann

5Department of Molecular and Cellular Biology, Roswell Park Cancer Institute, Buffalo, NY 14263, USA.

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Dipankar Bandyopadhyay

8Department of Biostatistics, Virginia Commonwealth University School of Medicine, Richmond, VA 23298, USA.

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Kazuaki Takabe

2Department of Biochemistry and Molecular Biology and Massey Cancer Center, Virginia Commonwealth University, Richmond, VA 23298, USA.

3Division of Surgical Oncology, Virginia Commonwealth University School of Medicine, Richmond, VA 23298, USA.

9Division of Breast Surgery, Department of Surgical Oncology, Roswell Park Cancer Institute, Buffalo, NY 14263, USA.

10Department of Surgery, Jacobs School of Medicine and Biomedical Sciences, University at Buffalo, State University of New York, Buffalo, NY 14203, USA.

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Andrew C. Larner

2Department of Biochemistry and Molecular Biology and Massey Cancer Center, Virginia Commonwealth University, Richmond, VA 23298, USA.

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For correspondence: andrew.larner@vcuhealth.org

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Stress-induced dynamic regulation of mitochondrial STAT3 and its association with cyclophilin D reduce mitochondrial ROS production

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